Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers
about
Heteromerization of G protein-coupled receptors: relevance to neurological disorders and neurotherapeutics.Receptor heteromerization and drug discovery.Genetic susceptibility to heroin addiction: a candidate gene association studyBeta-arrestin-dependent mu-opioid receptor-activated extracellular signal-regulated kinases (ERKs) Translocate to Nucleus in Contrast to G protein-dependent ERK activationBeta-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transductionOpioid receptor trafficking and interaction in nociceptorsAntibodies to probe endogenous G protein-coupled receptor heteromer expression, regulation, and functionOpioid receptors: toward separation of analgesic from undesirable effectsOpioid receptor heteromers in analgesiaBiological redundancy of endogenous GPCR ligands in the gut and the potential for endogenous functional selectivityReceptor heteromerization expands the repertoire of cannabinoid signaling in rodent neuronsAnti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonismTolerance and withdrawal from prolonged opioid use in critically ill children.Endogenous morphine in SH-SY5Y cells and the mouse cerebellumEndogenous morphine levels are increased in sepsis: a partial implication of neutrophils.The physical association of the P2Y12 receptor with PAR4 regulates arrestin-mediated Akt activation.Putative kappa opioid heteromers as targets for developing analgesics free of adverse effects.CB2 Cannabinoid receptors as a therapeutic target-what does the future hold?Alterations of CXCR4 function in μ-opioid receptor-deficient glia.Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity.Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications.Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR review 10.Exploring a role for heteromerization in GPCR signalling specificity.Differential response to morphine of the oligomeric state of μ-opioid in the presence of δ-opioid receptorsHeteromers of μ-δ opioid receptors: new pharmacology and novel therapeutic possibilities.Recent advances on the δ opioid receptor: from trafficking to function.In vivo opioid receptor heteromerization: where do we stand?Change in functional selectivity of morphine with the development of antinociceptive tolerance.Ligand requirements for involvement of PKCε in synergistic analgesic interactions between spinal μ and δ opioid receptors.Heteromerization of the μ- and δ-opioid receptors produces ligand-biased antagonism and alters μ-receptor traffickingCharacterization of a MAPK scaffolding protein logic gate in gonadotropes.G protein-coupled receptor heteromerization: a role in allosteric modulation of ligand binding.AT1R-CB₁R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II.Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3Agonist-directed interactions with specific beta-arrestins determine mu-opioid receptor trafficking, ubiquitination, and dephosphorylation.CXCR7/CXCR4 heterodimer constitutively recruits beta-arrestin to enhance cell migration.Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment.Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance.Inhibition of EGF-induced ERK/MAP kinase-mediated astrocyte proliferation by mu opioids: integration of G protein and beta-arrestin 2-dependent pathways.Engineering endomorphin drugs: state of the art.
P2860
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P2860
Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers
description
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im August 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/08/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/08/01)
@nl
наукова стаття, опублікована в серпні 2007
@uk
مقالة علمية (نشرت في أغسطس 2007)
@ar
name
Receptor heterodimerization le ...... a opioid receptor heterodimers
@ast
Receptor heterodimerization le ...... a opioid receptor heterodimers
@en
Receptor heterodimerization le ...... a opioid receptor heterodimers
@nl
type
label
Receptor heterodimerization le ...... a opioid receptor heterodimers
@ast
Receptor heterodimerization le ...... a opioid receptor heterodimers
@en
Receptor heterodimerization le ...... a opioid receptor heterodimers
@nl
prefLabel
Receptor heterodimerization le ...... a opioid receptor heterodimers
@ast
Receptor heterodimerization le ...... a opioid receptor heterodimers
@en
Receptor heterodimerization le ...... a opioid receptor heterodimers
@nl
P2860
P356
P1433
P1476
Receptor heterodimerization le ...... a opioid receptor heterodimers
@en
P2093
Lakshmi A. Devi
Raphael Rozenfeld
P2860
P304
P356
10.1096/FJ.06-7793COM
P407
P577
2007-08-01T00:00:00Z