The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear.
about
Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisisThe Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis.Frizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat CancerPlanar cell polarity signaling pathway in congenital heart diseasesThe PTK7-related transmembrane proteins off-track and off-track 2 are co-receptors for Drosophila Wnt2 required for male fertilityA PTK7/Ror2 Co-Receptor Complex Affects Xenopus Neural Crest MigrationReceptor tyrosine kinase signaling: regulating neural crest development one phosphate at a timePTK7-Src signaling at epithelial cell contacts mediates spatial organization of actomyosin and planar cell polarity.PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium.Genetics of auditory mechano-electrical transduction.Protein-tyrosine pseudokinase 7 (PTK7) directs cancer cell motility and metastasis.Testin interacts with vangl2 genetically to regulate inner ear sensory cell orientation and the normal development of the female reproductive tract in mice.ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease.Brainstem respiratory oscillators develop independently of neuronal migration defects in the Wnt/PCP mouse mutant looptail.Atmin mediates kidney morphogenesis by modulating Wnt signaling.Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice.Potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (PTK7) chuzhoi by membrane type 1 matrix metalloproteinase (MT1-MMP) to congenital defects.Focusing forward genetics: a tripartite ENU screen for neurodevelopmental mutations in the mousePlanar polarity: A new player in both lung development and diseaseThe polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis.Matrix metalloproteinases - From the cleavage data to the prediction tools and beyond.The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled.The PTK7 and ROR2 Protein Receptors Interact in the Vertebrate WNT/Planar Cell Polarity (PCP) Pathway.Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung.Profiling analysis of long non-coding RNAs in early postnatal mouse hearts.Wnt5a: its signalling, functions and implication in diseases.Principles of planar polarity in animal developmentGetting to the heart of planar cell polarity signaling.Planar cell polarity: coordinating morphogenetic cell behaviors with embryonic polarityThe planar cell polarity pathway in vertebrate epidermal development, homeostasis and repair.The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man.A consideration of the evidence that genetic defects in planar cell polarity contribute to the etiology of human neural tube defects.Expanding the mutational spectrum associated to neural tube defects: literature revision and description of novel VANGL1 mutations.Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion.Planar cell polarity (PCP) proteins and spermatogenesis.Prickle1 regulates neurite outgrowth of apical spiral ganglion neurons but not hair cell polarity in the murine cochlea.PTK7 Faces the Wnt in Development and Disease.Cilia and Ciliopathies in Congenital Heart Disease.The non-canonical Wnt-PCP pathway shapes the caudal neural plate.Digenic variants of planar cell polarity genes in human neural tube defect patients.
P2860
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P2860
The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear.
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The novel mouse mutant, chuzho ...... lanar cell polarity in the ear
@nl
The novel mouse mutant, chuzho ...... anar cell polarity in the ear.
@ast
The novel mouse mutant, chuzho ...... anar cell polarity in the ear.
@en
type
label
The novel mouse mutant, chuzho ...... lanar cell polarity in the ear
@nl
The novel mouse mutant, chuzho ...... anar cell polarity in the ear.
@ast
The novel mouse mutant, chuzho ...... anar cell polarity in the ear.
@en
prefLabel
The novel mouse mutant, chuzho ...... lanar cell polarity in the ear
@nl
The novel mouse mutant, chuzho ...... anar cell polarity in the ear.
@ast
The novel mouse mutant, chuzho ...... anar cell polarity in the ear.
@en
P2093
P2860
P921
P3181
P356
P1476
The novel mouse mutant, chuzho ...... anar cell polarity in the ear.
@en
P2093
Alexander Ermakov
Anju Paudyal
Caroline Formstone
Charlotte H Dean
Christine Damrau
Deborah J Henderson
Dominic P Norris
Jennifer N Murdoch
Sara Wells
Victoria L Patterson
P2860
P2888
P3181
P356
10.1186/1471-213X-10-87
P577
2010-08-12T00:00:00Z
P5875
P6179
1040229757