Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
about
A heparin binding synthetic peptide from human HIP / RPL29 fails to specifically differentiate between anticoagulantly active and inactive species of heparinFormation of active monomers from tetrameric human beta-tryptaseActive monomers of human beta-tryptase have expanded substrate specificitiesDegranulating mast cells in fibrotic regions of human tumors and evidence that mast cell heparin interferes with the growth of tumor cells through a mechanism involving fibroblastsPathophysiology of heparan sulphate: many diseases, few drugsHuman genetic disorders and knockout mice deficient in glycosaminoglycanHeparan sulfate biosynthesis enzymes in embryonic stem cell biologyMast cell proteoglycansHeparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase ICrystal structure of beta 1,3-glucuronyltransferase I in complex with active donor substrate UDP-GlcUAMast cell modulation of the vascular and lymphatic endotheliumProcessing of Factor XII during Inflammatory ReactionsHeparin/heparan sulfate biosynthesis: processive formation of N-sulfated domainsNewly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinasesSerglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storageMast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axisSerglycin is the major secreted proteoglycan in macrophages and has a role in the regulation of macrophage tumor necrosis factor-alpha secretion in response to lipopolysaccharideThe molecular phenotype of heparan sulfate in the Hs2st-/- mutant mouseExtended substrate specificity of rat mast cell protease 5, a rodent alpha-chymase with elastase-like primary specificityParanodal junction formation and spermatogenesis require sulfoglycolipidsA role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule componentsMice lacking histidine decarboxylase exhibit abnormal mast cellsStructural requirements and mechanism for heparin-induced activation of a recombinant mouse mast cell tryptase, mouse mast cell protease-6: formation of active tryptase monomers in the presence of low molecular weight heparinCharacterization of the D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfateMultiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin IIThe chymase, mouse mast cell protease 4, constitutes the major chymotrypsin-like activity in peritoneum and ear tissue. A role for mouse mast cell protease 4 in thrombin regulation and fibronectin turnoverStimuli from conspecifics influence brain mast cell population in male rats.Altered heparan sulfate structure in mice with deleted NDST3 gene function.Heparan sulfate: lessons from knockout miceSLC10A4 regulates IgE-mediated mast cell degranulation in vitro and mast cell-mediated reactions in vivo3-O-sulfated oligosaccharide structures are recognized by anti-heparan sulfate antibody HS4C3.Synthesis of heparan sulfate with cyclophilin B-binding properties is determined by cell type-specific expression of sulfotransferases.Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in miceInfluence of sex, estrous cycle, and estrogen on intracranial dural mast cells.Biological implications of preformed mast cell mediators.Polyamines are present in mast cell secretory granules and are important for granule homeostasis.Heparan 2-O-sulfotransferase, hst-2, is essential for normal cell migration in Caenorhabditis elegans.Mice deficient in N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase are unable to synthesize chondroitin/dermatan sulfate containing N-acetylgalactosamine 4,6-bissulfate residues and exhibit decreased protease activity in bone marrow-derived mastDevelopment of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing.
P2860
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P2860
Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
description
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 1999
@ast
scientific journal article
@en
vedecký článok (publikovaný 1999/08/19)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/08/19)
@nl
наукова стаття, опублікована в серпні 1999
@uk
مقالة علمية (نشرت في 19-8-1999)
@ar
name
Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
@ast
Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
@en
Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
@nl
type
label
Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
@ast
Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
@en
Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
@nl
prefLabel
Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
@ast
Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
@en
Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
@nl
P2093
P3181
P356
P1433
P1476
Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
@en
P2093
B. Tomasini-Johansson
C. Lunderius
E. Forsberg
I. Eriksson
L. Hellman
M. Kusche-Gullberg
M. Ringvall
P2888
P304
P3181
P356
10.1038/23488
P407
P577
1999-08-19T00:00:00Z
P5875
P6179
1009464730