The RhoGAP activity of OPHN1, a new F-actin-binding protein, is negatively controlled by its amino-terminal domain
about
A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbĪ±The human minor histocompatibility antigen 1 is a RhoGAPRegulation of small GTPases by GEFs, GAPs, and GDIsFunctional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine fingerReduced gamma oscillations in a mouse model of intellectual disability: a role for impaired repetitive neurotransmission?Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS.A novel in-frame deletion affecting the BAR domain of OPHN1 in a family with intellectual disability and hippocampal alterations.Model organisms inform the search for the genes and developmental pathology underlying malformations of the human hindbrain.The BNIP-2 and Cdc42GAP homology (BCH) domain of p50RhoGAP/Cdc42GAP sequesters RhoA from inactivation by the adjacent GTPase-activating protein domain.Characterization of a novel GTPase-activating protein associated with focal adhesions and the actin cytoskeleton.Control of synapse development and plasticity by Rho GTPase regulatory proteins.Oligophrenin-1 (OPHN1), a gene involved in X-linked intellectual disability, undergoes RNA editing and alternative splicing during human brain development.Rho-linked genes and neurological disorders.Current knowledge of the large RhoGAP family of proteins.Mosaicism for r(X) and der(X)del(X)(p11.23)dup(X)(p11.21p11.22) provides insight into the possible mechanism of rearrangement.Report of a female patient with mental retardation and tall stature due to a chromosomal rearrangement disrupting the OPHN1 gene on Xq12Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway.Inhibition and termination of physiological responses by GTPase activating proteins.Reversing synapse loss in Alzheimer's disease: Rho-guanosine triphosphatases and insights from other brain disorders.Lymphovascular invasion is associated with poor survival in gastric cancer: an application of gene-expression and tissue array techniques.Oligophrenin-1 regulates number, morphology and synaptic properties of adult-born inhibitory interneurons in the olfactory bulb.Drebrins and Connexins: A Biomedical Perspective.Inhibition of RhoA pathway rescues the endocytosis defects in Oligophrenin1 mouse model of mental retardation.Pharmacological rescue of adult hippocampal neurogenesis in a mouse model of X-linked intellectual disability.Adult neurogenesis in intellectual disabilities.GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins.Autoinhibition of p50 Rho GTPase-activating protein (GAP) is released by prenylated small GTPases.Insertion of 16 amino acids in the BAR domain of the oligophrenin 1 protein causes mental retardation and cerebellar hypoplasia in an Italian family.The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis.Rapid reversal of impaired inhibitory and excitatory transmission but not spine dysgenesis in a mouse model of mental retardation.Additive lymph node dissection may be necessary in minute submucosal cancer of the stomach after endoscopic resection.Deletion of the OPHN1 gene detected by aCGH.Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities.
P2860
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P2860
The RhoGAP activity of OPHN1, a new F-actin-binding protein, is negatively controlled by its amino-terminal domain
description
2003 Õ©ÕøÖÕ”ÕÆÕ”Õ¶Õ« ÕÕ£ÕøÕ½ÕæÕøÕ½Õ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕøÖÕ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ ÕµÖ
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@hyw
2003 Õ©Õ¾Õ”ÕÆÕ”Õ¶Õ« Ö
Õ£ÕøÕ½ÕæÕøÕ½Õ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕ¾Õ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ Õ°ÕøÕ¤Õ¾Õ”Õ®
@hy
artĆculu cientĆficu espublizĆ”u en 2003
@ast
im August 2003 verƶffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedeckĆ½ ÄlĆ”nok (publikovanĆ½ 2003/08/01)
@sk
vÄdeckĆ½ ÄlĆ”nek publikovanĆ½ v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/08/01)
@nl
Š½Š°ŃŠŗŠ¾Š²Š° ŃŃŠ°ŃŃŃ, Š¾ŠæŃŠ±Š»ŃŠŗŠ¾Š²Š°Š½Š° Š² ŃŠµŃŠæŠ½Ń 2003
@uk
Ł
ŁŲ§ŁŲ© Ų¹ŁŁ
ŁŲ© (ŁŲ“Ų±ŲŖ ŁŁ Ų£ŲŗŲ³Ų·Ų³ 2003)
@ar
name
The RhoGAP activity of OPHN1, ...... d by its amino-terminal domain
@ast
The RhoGAP activity of OPHN1, ...... d by its amino-terminal domain
@en
The RhoGAP activity of OPHN1, ...... d by its amino-terminal domain
@nl
type
label
The RhoGAP activity of OPHN1, ...... d by its amino-terminal domain
@ast
The RhoGAP activity of OPHN1, ...... d by its amino-terminal domain
@en
The RhoGAP activity of OPHN1, ...... d by its amino-terminal domain
@nl
prefLabel
The RhoGAP activity of OPHN1, ...... d by its amino-terminal domain
@ast
The RhoGAP activity of OPHN1, ...... d by its amino-terminal domain
@en
The RhoGAP activity of OPHN1, ...... d by its amino-terminal domain
@nl
P2093
P50
P1476
The RhoGAP activity of OPHN1, ...... d by its amino-terminal domain
@en
P2093
Alexander Eberth
Fabien Fauchereau
Marie-Claude Vinet
Philippe Chafey
Ulrike Herbrand
P304
P356
10.1016/S1044-7431(03)00078-2
P577
2003-08-01T00:00:00Z