Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization
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Munc18-bound syntaxin readily forms SNARE complexes with synaptobrevin in native plasma membranesDOC2B: a novel syntaxin-4 binding protein mediating insulin-regulated GLUT4 vesicle fusion in adipocytesCargos and genes: insights into vesicular transport from inherited human diseaseInsulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5Negative regulation of syntaxin4/SNAP-23/VAMP2-mediated membrane fusion by Munc18c in vitroMunc18c depletion selectively impairs the sustained phase of insulin releaseAQP2 exocytosis in the renal collecting duct -- involvement of SNARE isoforms and the regulatory role of Munc18bDifferential Effects of Munc18s on Multiple Degranulation-Relevant Trans-SNARE ComplexesMunc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cellsC1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetesInsulin signaling diverges into Akt-dependent and -independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membraneRETRACTED: The SNARE protein SNAP23 and the SNARE-interacting protein Munc18c in human skeletal muscle are implicated in insulin resistance/type 2 diabetes.Current views on type 2 diabetes.The GLUT4 codeSpatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis.Exocytosis mechanisms underlying insulin release and glucose uptake: conserved roles for Munc18c and syntaxin 4Tyrosine phosphorylation of Munc18c on residue 521 abrogates binding to Syntaxin 4The role of syntaxins in the specificity of vesicle targeting in polarized epithelial cells.α3(V) collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissuesMunc18c: a controversial regulator of peripheral insulin action.The syntaxin 4 N terminus regulates its basolateral targeting by munc18c-dependent and -independent mechanismsPI 4,5-P2 stimulates glucose transport activity of GLUT4 in the plasma membrane of 3T3-L1 adipocytes.GLUT4 exocytosis.Protein expression of PKCZ (Protein Kinase C Zeta), Munc18c, and Syntaxin-4 in the insulin pathway in endometria of patients with polycystic ovary syndrome (PCOS)MUNC-ing around with insulin action.Turning signals on and off: GLUT4 traffic in the insulin-signaling highway.Insulin signaling and the regulation of glucose transport.Glucose transporter 4: cycling, compartments and controversies.Munc18-1 is critical for plasma membrane localization of syntaxin1 but not of SNAP-25 in PC12 cells.Munc18c is not rate-limiting for glucose and long-chain fatty acid uptake in the heartThe stimulus-induced tyrosine phosphorylation of Munc18c facilitates vesicle exocytosis."Actin"g on GLUT4: membrane & cytoskeletal components of insulin action.Emerging roles of phosphatidylinositol 3-monophosphate as a dynamic lipid second messenger.Phosphoinositides in insulin action on GLUT4 dynamics: not just PtdIns(3,4,5)P3.Ins (endocytosis) and outs (exocytosis) of GLUT4 traffickingSpecialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs.Rescue of Munc18-1 and -2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells.Munc18-2 and syntaxin 3 control distinct essential steps in mast cell degranulationSNARE proteins underpin insulin-regulated GLUT4 traffic.The SNARE Machinery in Mast Cell Secretion.
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P2860
Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization
description
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im Februar 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/02/01)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/02/01)
@nl
наукова стаття, опублікована в лютому 2005
@uk
مقالة علمية (نشرت في فبراير 2005)
@ar
name
Adipocytes from Munc18c-null m ...... imulated GLUT4 externalization
@ast
Adipocytes from Munc18c-null m ...... imulated GLUT4 externalization
@en
Adipocytes from Munc18c-null m ...... imulated GLUT4 externalization
@nl
type
label
Adipocytes from Munc18c-null m ...... imulated GLUT4 externalization
@ast
Adipocytes from Munc18c-null m ...... imulated GLUT4 externalization
@en
Adipocytes from Munc18c-null m ...... imulated GLUT4 externalization
@nl
prefLabel
Adipocytes from Munc18c-null m ...... imulated GLUT4 externalization
@ast
Adipocytes from Munc18c-null m ...... imulated GLUT4 externalization
@en
Adipocytes from Munc18c-null m ...... imulated GLUT4 externalization
@nl
P2093
P2860
P356
P1476
Adipocytes from Munc18c-null m ...... imulated GLUT4 externalization
@en
P2093
Fumi Tashiro
Hajime Kanda
Hiroaki Shinoda
Hiroki Otani
Jun Udagawa
Jun-Ichi Miyazaki
Mari Yoshikawa
Masato Kasuga
Motoyoshi Sakaue
Yoshikazu Tamori
P2860
P304
P356
10.1172/JCI22681
P407
P577
2005-02-01T00:00:00Z