Essential role of limiting telomeres in the pathogenesis of Werner syndrome
about
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cellsPOT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substratesSIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatinThe RecQ DNA helicases in DNA repairHuman RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biologyThe telomere syndromesShort telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR miceChromatin regulation and genome maintenance by mammalian SIRT6Roles of Werner syndrome protein in protection of genome integrityModel of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromesHuman premature aging, DNA repair and RecQ helicasesEvidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence.trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase.Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cellsDNA Damage: A Main Determinant of Vascular AgingThe telomeric sync model of speciation: species-wide telomere erosion triggers cycles of transposon-mediated genomic rearrangements, which underlie the saltatory appearance of nonadaptive charactersModeling the study of DNA damage responses in miceAn overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial jointsPleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammationAxis of ageing: telomeres, p53 and mitochondriaTelomere shortening in human diseasesc-Myc accelerates S-phase and requires WRN to avoid replication stressRecQ helicases in DNA double strand break repair and telomere maintenance.Evidence that a RecQ helicase slows senescence by resolving recombining telomeresTelomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventionsLinking functional decline of telomeres, mitochondria and stem cells during ageingWRN loss induces switching of telomerase-independent mechanisms of telomere elongationThe DNA structure and sequence preferences of WRN underlie its function in telomeric recombination eventsOpposing impacts on healthspan and longevity by limiting dietary selenium in telomere dysfunctional miceTelomeres and human disease: ageing, cancer and beyondEarly aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clockTelomere Length Maintenance and Cardio-Metabolic Disease Prevention Through Exercise Training.The role of mitochondrial DNA mutations in mammalian agingMechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicaseTelomeres and disease.Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenitaThe Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks.Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis.WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1.
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Essential role of limiting telomeres in the pathogenesis of Werner syndrome
description
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
articolo scientifico
@it
artículu científicu espublizáu en 2004
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im August 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/08/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/08/01)
@nl
наукова стаття, опублікована в серпні 2004
@uk
name
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
@ast
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
@en
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
@nl
type
label
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
@ast
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
@en
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
@nl
prefLabel
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
@ast
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
@en
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
@nl
P2093
P2860
P3181
P356
P1433
P1476
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
@en
P2093
Asha S. Multani
Leonard Guarente
Maria L. Naylor
Noelia G. Cabrera
Purnima Laud
Ronald A. DePinho
Sandy Chang
Sen Pathak
P2860
P2888
P304
P3181
P356
10.1038/NG1389
P407
P577
2004-08-01T00:00:00Z