Mena is required for neurulation and commissure formation
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Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumorsFyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeletonThe orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domainSpectrin interacts with EVL (Enabled/vasodilator-stimulated phosphoprotein-like protein), a protein involved in actin polymerizationStructural basis for polyproline recognition by the FE65 WW domainCDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASPProfilin II is alternatively spliced, resulting in profilin isoforms that are differentially expressed and have distinct biochemical propertiesHow to form and close the brain: insight into the mechanism of cranial neural tube closure in mammalsEna/VASP: towards resolving a pointed controversy at the barbed endDisruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosumRole of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenesCell type-dependent mechanisms for formin-mediated assembly of filopodia.Reconstitution of actin-based motility by vasodilator-stimulated phosphoprotein (VASP) depends on the recruitment of F-actin seeds from the solution produced by cofilin.Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways.Fluxes of water through aquaporin 9 weaken membrane-cytoskeleton anchorage and promote formation of membrane protrusionsHuman Mena associates with Rac1 small GTPase in glioblastoma cell linesThe beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocationAbl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinaseReceptor protein tyrosine phosphatases in nervous system developmentThe beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogeneMultiple signaling interactions of Abl and Arg kinases with the EphB2 receptorEssential roles for the FE65 amyloid precursor protein-interacting proteins in brain developmentProfilin I is essential for cell survival and cell division in early mouse developmentCallosal axon guidance defects in p35(-/-) miceBrain armadillo protein delta-catenin interacts with Abl tyrosine kinase and modulates cellular morphogenesis in response to growth factorsc-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesisThe adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signalingModulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extensionSrg3, a mouse homolog of yeast SWI3, is essential for early embryogenesis and involved in brain developmentMechanism of filopodia initiation by reorganization of a dendritic network.Vasodilator-stimulated phosphoprotein (VASP) induces actin assembly in dendritic spines to promote their development and potentiate synaptic strength.Formation of filopodia-like bundles in vitro from a dendritic network.Ena/VASP proteins have an anti-capping independent function in filopodia formation.ARNO and ARF6 regulate axonal elongation and branching through downstream activation of phosphatidylinositol 4-phosphate 5-kinase alphaCritical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration.Ena/VASP proteins can regulate distinct modes of actin organization at cadherin-adhesive contacts.N- and E-cadherins in Xenopus are specifically required in the neural and non-neural ectoderm, respectively, for F-actin assembly and morphogenetic movements.A novel genetic mechanism regulates dorsolateral hinge-point formation during zebrafish cranial neurulation.Ena drives invasive macrophage migration in Drosophila embryos.Ena/VASP function in retinal axons is required for terminal arborization but not pathway navigation.
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P248
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P2860
Mena is required for neurulation and commissure formation
description
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1999
@ast
im Februar 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/02/01)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/02/01)
@nl
наукова стаття, опублікована в лютому 1999
@uk
مقالة علمية (نشرت في فبراير 1999)
@ar
name
Mena is required for neurulation and commissure formation
@ast
Mena is required for neurulation and commissure formation
@en
Mena is required for neurulation and commissure formation
@nl
type
label
Mena is required for neurulation and commissure formation
@ast
Mena is required for neurulation and commissure formation
@en
Mena is required for neurulation and commissure formation
@nl
prefLabel
Mena is required for neurulation and commissure formation
@ast
Mena is required for neurulation and commissure formation
@en
Mena is required for neurulation and commissure formation
@nl
P2093
P3181
P1433
P1476
Mena is required for neurulation and commissure formation
@en
P2093
A. M. Wehman
A. S. Menzies
D. Kwiatkowski
F. B. Gertler
J. D. Macklis
L. M. Lanier
M. A. Gates
P. Soriano
P304
P3181
P356
10.1016/S0896-6273(00)81092-2
P407
P577
1999-02-01T00:00:00Z