Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation
about
Function, regulation and pathological roles of the Gab/DOS docking proteinsThe molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesisBivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative mannerPrinciples of interleukin (IL)-6-type cytokine signalling and its regulationPKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation.Grb2-associated binding (Gab) proteins in hematopoietic and immune cell biologyA novel role for Gab2 in bFGF-mediated cell survival during retinoic acid-induced neuronal differentiationMET: a critical player in tumorigenesis and therapeutic targetBiology of MET: a double life between normal tissue repair and tumor progressionThe role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptorsRole of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo)Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factorGab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signalingOrder and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategiesEssential role for ERK2 mitogen-activated protein kinase in placental developmentHOXA13 Is essential for placental vascular patterning and labyrinth endothelial specificationGab3, a new DOS/Gab family member, facilitates macrophage differentiation.ERK regulates the hepatocyte growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinaseMouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutationDefective extraembryonic angiogenesis in mice lacking LBP-1a, a member of the grainyhead family of transcription factorsGab1 is an integrator of cell death versus cell survival signals in oxidative stressThe signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold.Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion.Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo.Altered trophoblast proliferation is insufficient to account for placental dysfunction in Egfr null embryosDistinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis.A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase.Both src-dependent and -independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors.Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinaseExpression of Gab1 lacking the pleckstrin homology domain is associated with neoplastic progression.Gene expression analysis of mammary tissue during fetal bud formation and growth in two pig breeds--indications of prenatal initiation of postnatal phenotypic differencesRegulation of kidney development by Shp2: an unbiased stereological analysis.Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: annotated tables.Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells.Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway.Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent.Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesisBinding of the cSH3 domain of Grb2 adaptor to two distinct RXXK motifs within Gab1 docker employs differential mechanisms.
P2860
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P2860
Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation
description
2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im Mai 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/05/01)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/05/01)
@nl
наукова стаття, опублікована в травні 2000
@uk
مقالة علمية (نشرت في مايو 2000)
@ar
name
Role of Gab1 in heart, placent ...... ated protein kinase activation
@ast
Role of Gab1 in heart, placent ...... ated protein kinase activation
@en
Role of Gab1 in heart, placent ...... ated protein kinase activation
@nl
type
label
Role of Gab1 in heart, placent ...... ated protein kinase activation
@ast
Role of Gab1 in heart, placent ...... ated protein kinase activation
@en
Role of Gab1 in heart, placent ...... ated protein kinase activation
@nl
prefLabel
Role of Gab1 in heart, placent ...... ated protein kinase activation
@ast
Role of Gab1 in heart, placent ...... ated protein kinase activation
@en
Role of Gab1 in heart, placent ...... ated protein kinase activation
@nl
P2093
P2860
P3181
P1476
Role of Gab1 in heart, placent ...... ated protein kinase activation
@en
P2093
P2860
P304
P3181
P356
10.1128/MCB.20.10.3695-3704.2000
P407
P577
2000-05-01T00:00:00Z