Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene
about
Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusersThe NR4A subgroup: immediate early response genes with pleiotropic physiological rolesCooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype.Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neuronsMultiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor NURR1A Compendium of Preparation and Application of Stem Cells in Parkinson's Disease: Current Status and Future ProspectsNuclear receptors in bone physiology and diseasesRequirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptorsDifferential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5aBrn3a and Nurr1 mediate a gene regulatory pathway for habenula developmentHes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain.Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant miceInvolvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neuronsHeterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activationEffects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in miceA response element for the homeodomain transcription factor Ptx3 in the tyrosine hydroxylase gene promoterZENON, a novel POZ Kruppel-like DNA binding protein associated with differentiation and/or survival of late postmitotic neuronsp57(Kip2) cooperates with Nurr1 in developing dopamine cellsnor-1 regulates hippocampal axon guidance, pyramidal cell survival, and seizure susceptibilityChronic Toxoplasma gondii in Nurr1-null heterozygous mice exacerbates elevated open field activityNur transcription factors in stress and addictionDistribution of the orphan nuclear receptor Nurr1 in medaka (Oryzias latipes): cues to the definition of homologous cell groups in the vertebrate brain.Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism.Embryonic development of selectively vulnerable neurons in Parkinson's disease.NR4A gene expression is dynamically regulated in the ventral tegmental area dopamine neurons and is related to expression of dopamine neurotransmission genes.Gene expression profiling of embryonic human neural stem cells and dopaminergic neurons from adult human substantia nigraMutation analysis of the human NR4A2 gene, an essential gene for midbrain dopaminergic neurogenesis, in schizophrenic patients.Mutations in NR4A2 associated with familial Parkinson disease.The constitutive and inducible expression of Nurr1, a key regulator of dopaminergic neuronal differentiation, in human neural and non-neural cell lines.Age-related changes in dopamine signaling in Nurr1 deficient mice as a model of Parkinson's diseasePIASgamma represses the transcriptional activation induced by the nuclear receptor Nurr1.Restriction of neural precursor ability to respond to Nurr1 by early regional specification.Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons.Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells.The role of NR4A transcription factors in memory formationNGF-induced cell differentiation and gene activation is mediated by integrative nuclear FGFR1 signaling (INFS).Pitx3 is required for development of substantia nigra dopaminergic neurons.Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repairKnockdown of Nurr1 in the rat hippocampus: implications to spatial discrimination learning and memory.Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease
P2860
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P2860
Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene
description
1998 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1998
@ast
im Mai 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/05/01)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/05/01)
@nl
наукова стаття, опублікована в травні 1998
@uk
مقالة علمية (نشرت في مايو 1998)
@ar
name
Dopamine biosynthesis is selec ...... d disruption of the Nurr1 gene
@ast
Dopamine biosynthesis is selec ...... d disruption of the Nurr1 gene
@en
Dopamine biosynthesis is selec ...... d disruption of the Nurr1 gene
@nl
type
label
Dopamine biosynthesis is selec ...... d disruption of the Nurr1 gene
@ast
Dopamine biosynthesis is selec ...... d disruption of the Nurr1 gene
@en
Dopamine biosynthesis is selec ...... d disruption of the Nurr1 gene
@nl
prefLabel
Dopamine biosynthesis is selec ...... d disruption of the Nurr1 gene
@ast
Dopamine biosynthesis is selec ...... d disruption of the Nurr1 gene
@en
Dopamine biosynthesis is selec ...... d disruption of the Nurr1 gene
@nl
P2093
P921
P3181
P356
P1476
Dopamine biosynthesis is selec ...... d disruption of the Nurr1 gene
@en
P2093
P3181
P356
10.1006/MCNE.1998.0673
P577
1998-05-01T00:00:00Z