Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells
about
The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targetingMolecular architecture of quartet MOZ/MORF histone acetyltransferase complexesMOZ and MORF, two large MYSTic HATs in normal and cancer stem cellsERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specificationMolecular basis of cleft palates in micePartners in crime: The role of tandem modules in gene transcriptionThe double PHD finger domain of MOZ/MYST3 induces -helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modificationCombinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcriptionHistone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancyThe Role of Histone Acetyltransferases in Normal and Malignant HematopoiesisMultiple recurrent genetic events converge on control of histone lysine methylation in medulloblastomaHBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic developmentMOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndromeMutations in the Chromatin Regulator Gene BRPF1 Cause Syndromic Intellectual Disability and Deficient Histone AcetylationHomozygous disruption of the Tip60 gene causes early embryonic lethality.Expression atlas of the multivalent epigenetic regulator Brpf1 and its requirement for survival of mouse embryos.Regulation of germinal center responses and B-cell memory by the chromatin modifier MOZAn efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets.Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity.The lysine acetyltransferase activator Brpf1 governs dentate gyrus development through neural stem cells and progenitors.The chromatin regulator Brpf1 regulates embryo development and cell proliferationBivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation.PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2Males absent on the first (MOF): from flies to humans.The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identityChromatin regulatory mechanisms in pluripotency.Dominant mutations in KAT6A cause intellectual disability with recognizable syndromic features.De novo nonsense mutations in KAT6A, a lysine acetyl-transferase gene, cause a syndrome including microcephaly and global developmental delayMOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo.Runx1 loss minimally impacts long-term hematopoietic stem cellsMOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development.MicroRNA 665 Regulates Dentinogenesis through MicroRNA-Mediated Silencing and Epigenetic MechanismsMof (MYST1 or KAT8) is essential for progression of embryonic development past the blastocyst stage and required for normal chromatin architecture.The MYST family of histone acetyltransferases and their intimate links to cancer.Leukemia and hematopoietic stem cells: balancing proliferation and quiescence.Bloodlines of haematopoietic stem cell research in Japan.Alcohol-induced protein hyperacetylation: mechanisms and consequencesThe histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors.BRPF1 is essential for development of fetal hematopoietic stem cellsSTAT5 is crucial to maintain leukemic stem cells in acute myelogenous leukemias induced by MOZ-TIF2.
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P2860
Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells
description
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
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im Mai 2006 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2006/05/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/05/01)
@nl
наукова стаття, опублікована в травні 2006
@uk
مقالة علمية (نشرت في مايو 2006)
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name
Monocytic leukemia zinc finger ...... uting hematopoietic stem cells
@ast
Monocytic leukemia zinc finger ...... uting hematopoietic stem cells
@en
Monocytic leukemia zinc finger ...... uting hematopoietic stem cells
@nl
type
label
Monocytic leukemia zinc finger ...... uting hematopoietic stem cells
@ast
Monocytic leukemia zinc finger ...... uting hematopoietic stem cells
@en
Monocytic leukemia zinc finger ...... uting hematopoietic stem cells
@nl
prefLabel
Monocytic leukemia zinc finger ...... uting hematopoietic stem cells
@ast
Monocytic leukemia zinc finger ...... uting hematopoietic stem cells
@en
Monocytic leukemia zinc finger ...... uting hematopoietic stem cells
@nl
P2093
P2860
P356
P1433
P1476
Monocytic leukemia zinc finger ...... uting hematopoietic stem cells
@en
P2093
Anne K. Voss
Lynn M. Corcoran
Mathew P. Dixon
Raffi Gugasyan
Stephen L. Nutt
Thomas Brodnicki
Tim Thomas
P2860
P304
P356
10.1101/GAD.1382606
P577
2006-05-01T00:00:00Z