Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas
about
A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasisAn intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acidTargeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signalingThe many faces and functions of β-cateninPAF and EZH2 induce Wnt/β-catenin signaling hyperactivation.The regulation of β-catenin activity and function in cancer: therapeutic opportunitiesCrosstalk between microRNA30a/b/c/d/e-5p and the canonical Wnt pathway: implications for multiple myeloma therapyDefining new criteria for selection of cell-based intestinal models using publicly available databases.The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesisPax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development.Histotype-specific copy-number alterations in ovarian cancer.FOXQ1, a novel target of the Wnt pathway and a new marker for activation of Wnt signaling in solid tumors.Physiological and pathological role of local and immigrating colonic stem cellsEssential requirement for β-arrestin2 in mouse intestinal tumors with elevated Wnt signalingExpression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasionThe role of upregulated miRNAs and the identification of novel mRNA targets in prostatospheresGenome-wide mutation profiles of colorectal tumors and associated liver metastases at the exome and transcriptome levels.β-Catenin Upregulates the Constitutive and Virus-Induced Transcriptional Capacity of the Interferon Beta Promoter through T-Cell Factor Binding SitesBCL9/9L-β-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer.BCL9, a coactivator for Wnt/β-catenin transcription, is targeted by miR-30c and is associated with prostate cancer progression.Cooperation of cancer stem cell properties and epithelial-mesenchymal transition in the establishment of breast cancer metastasis.Epigenetic regulation of aging stem cells.Drugging Wnt signalling in cancerGenetic and non-genetic instability in tumor progression: link between the fitness landscape and the epigenetic landscape of cancer cells.miR-30-5p functions as a tumor suppressor and novel therapeutic tool by targeting the oncogenic Wnt/β-catenin/BCL9 pathway.Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing.Competitive binding of a benzimidazole to the histone-binding pocket of the Pygo PHD finger.Pharmacological interventions in the Wnt pathway: inhibition of Wnt secretion versus disrupting the protein-protein interfaces of nuclear factors.Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer.miR-1301 inhibits hepatocellular carcinoma cell migration, invasion, and angiogenesis by decreasing Wnt/β-catenin signaling through targeting BCL9.The role of Pygo2 for Wnt/ß-catenin signaling activity during intestinal tumor initiation and progression.Detailed Analysis of Focal Chromosome Arm 1q and 6p Amplifications in Urothelial Carcinoma Reveals Complex Genomic Events on 1q, and SOX4 as a Possible Auxiliary Target on 6p.Analysis of apoptosis methods recently used in Cancer Research and Cell Death & Disease publications.Structure-Based Design of 1,4-Dibenzoylpiperazines as β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction Inhibitors.Tuning WNT-β-catenin signaling via BCL9 proteins for targeting colorectal cancer cells.An emerging role for Wnt and GSK3 signaling pathways in schizophrenia.Linking dental pathologies and cancer via Wnt signalling.Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma.Compared proteomic analysis of 8- and 32-week-old postnatal porcine ovaries.miR-130a and miR-212 Disrupt the Intestinal Epithelial Barrier through Modulation of PPARγ and Occludin Expression in Chronic Simian Immunodeficiency Virus-Infected Rhesus Macaques.
P2860
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P2860
Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas
description
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2010
@ast
im August 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/08/15)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/08/15)
@nl
наукова стаття, опублікована в серпні 2010
@uk
مقالة علمية (نشرت في 15-8-2010)
@ar
name
Bcl9/Bcl9l are critical for Wn ...... epithelium and adenocarcinomas
@ast
Bcl9/Bcl9l are critical for Wn ...... epithelium and adenocarcinomas
@en
Bcl9/Bcl9l are critical for Wn ...... epithelium and adenocarcinomas
@nl
type
label
Bcl9/Bcl9l are critical for Wn ...... epithelium and adenocarcinomas
@ast
Bcl9/Bcl9l are critical for Wn ...... epithelium and adenocarcinomas
@en
Bcl9/Bcl9l are critical for Wn ...... epithelium and adenocarcinomas
@nl
prefLabel
Bcl9/Bcl9l are critical for Wn ...... epithelium and adenocarcinomas
@ast
Bcl9/Bcl9l are critical for Wn ...... epithelium and adenocarcinomas
@en
Bcl9/Bcl9l are critical for Wn ...... epithelium and adenocarcinomas
@nl
P2093
P921
P1433
P1476
Bcl9/Bcl9l are critical for Wn ...... epithelium and adenocarcinomas
@en
P2093
Fabienne Murphy-Seiler
Jean-Christophe Stehle
Jennyfer Bultinck
Jürgen Deka
Mauro Delorenzi
Michel Aguet
Nathalie Vilain
Norbert Wiedemann
Olav Zilian
Pascale Anderle
P304
P356
10.1158/0008-5472.CAN-10-0148
P407
P577
2010-08-03T00:00:00Z