Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity
about
LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues.Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression.SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling.LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion.Coordinated cell motility is regulated by a combination of LKB1 farnesylation and kinase activity.AMPK--sensing energy while talking to other signaling pathways.LKB1 Tumor Suppressor: Therapeutic Opportunities Knock when LKB1 Is Inactivated.Protein lipid modifications--More than just a greasy ballast.AMPK β1 reduces tumor progression and improves survival in p53 null mice.The interplay between cell signalling and the mevalonate pathway in cancer.AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance.The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs.AMPK potentiation by LKB1 isoforms.Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation.Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism.Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance.
P2860
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P2860
Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity
description
2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2014
@ast
im Februar 2014 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2014/02/15)
@sk
vědecký článek publikovaný v roce 2014
@cs
wetenschappelijk artikel (gepubliceerd op 2014/02/15)
@nl
наукова стаття, опублікована в лютому 2014
@uk
مقالة علمية (نشرت في 15-2-2014)
@ar
name
Investigation of LKB1 Ser431 p ...... on in regulating AMPK activity
@ast
Investigation of LKB1 Ser431 p ...... on in regulating AMPK activity
@en
Investigation of LKB1 Ser431 p ...... on in regulating AMPK activity
@nl
type
label
Investigation of LKB1 Ser431 p ...... on in regulating AMPK activity
@ast
Investigation of LKB1 Ser431 p ...... on in regulating AMPK activity
@en
Investigation of LKB1 Ser431 p ...... on in regulating AMPK activity
@nl
prefLabel
Investigation of LKB1 Ser431 p ...... on in regulating AMPK activity
@ast
Investigation of LKB1 Ser431 p ...... on in regulating AMPK activity
@en
Investigation of LKB1 Ser431 p ...... on in regulating AMPK activity
@nl
P2093
P2860
P50
P356
P1433
P1476
Investigation of LKB1 Ser431 p ...... on in regulating AMPK activity
@en
P2093
Joby Varghese
Natalia Shpiro
Robert Gourlay
Vanessa P Houde
P2860
P356
10.1042/BJ20131324
P407
P577
2014-02-15T00:00:00Z