The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity
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MafB is required for islet beta cell maturationTranscription factor regulation of pancreatic organogenesis, differentiation and maturationEpigenetic Regulation of Islet Development and RegenerationGenetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cellsSmall-molecule inhibitors of the cystic fibrosis transmembrane conductance regulator increase pancreatic endocrine cell development in rat and mouseExpression of zebrafish pax6b in pancreas is regulated by two enhancers containing highly conserved cis-elements bound by PDX1, PBX and PREP factorsRelative roles of the different Pax6 domains for pancreatic alpha cell development.Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineageMultiple enhancers located in a 1-Mb region upstream of POU3F4 promote expression during inner ear development and may be required for hearingTranscriptional regulation of α-cell differentiation.The developmental regulator Pax6 is essential for maintenance of islet cell function in the adult mouse pancreasCDKAL1-related single nucleotide polymorphisms are associated with insulin resistance in a cross-sectional cohort of Greek children.New insights into endocrine pancreatic development: the role of environmental factors.Pax6 Inactivation in the Adult Pancreas Reveals Ghrelin as Endocrine Cell Maturation MarkerThe MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells.Islet α-, β-, and δ-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor.Long-range downstream enhancers are essential for Pax6 expression.Karyopherins in nuclear transport of homeodomain proteins during development.Pancreas cell fate.Targeting pancreatic expressed PAX genes for the treatment of diabetes mellitus and pancreatic neuroendocrine tumors.Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.Nkx6.2 synergizes with Cdx-2 in stimulating proglucagon gene expression.Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression.The Pax6b homeodomain is dispensable for pancreatic endocrine cell differentiation in zebrafish.Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas.Phylogenetic and regulatory region analysis of Wnt5 genes reveals conservation of a regulatory module with putative implication in pancreas developmentGeneration of transplantable Beta cells for patient-specific cell therapy.Pax4 is not essential for beta-cell differentiation in zebrafish embryos but modulates alpha-cell generation by repressing arx gene expression.The CD34 surface antigen is restricted to glucagon-expressing cells in the early developing bovine pancreas.Loss of the imprinted, non-coding Snord116 gene cluster in the interval deleted in the Prader Willi syndrome results in murine neuronal and endocrine pancreatic developmental phenotypes.Single-cell analyses of human islet cells reveal de-differentiation signatures.Lineage dynamics of murine pancreatic development at single-cell resolutionEndocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis
P2860
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P2860
The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity
description
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im April 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/04/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/04/01)
@nl
наукова стаття, опублікована у квітні 2004
@uk
مقالة علمية (نشرت في أبريل 2004)
@ar
name
The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity
@ast
The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity
@en
The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity
@nl
type
label
The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity
@ast
The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity
@en
The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity
@nl
prefLabel
The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity
@ast
The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity
@en
The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity
@nl
P2093
P1476
The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity
@en
P2093
Doris A. Stoffers
E. Bryan Crenshaw
Ole D. Madsen
R. Scott Heller
P304
P356
10.1016/J.YDBIO.2003.12.008
P407
P577
2004-04-01T00:00:00Z