A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2
about
Autoinflammatory bone diseasesNuclear receptor coregulators: modulators of pathology and therapeutic targetsLipins, lipinopathies, and the modulation of cellular lipid storage and signalingPhosphorylation regulates the ubiquitin-independent degradation of yeast Pah1 phosphatidate phosphatase by the 20S proteasome.Yeast Nem1-Spo7 protein phosphatase activity on Pah1 phosphatidate phosphatase is specific for the Pho85-Pho80 protein kinase phosphorylation sites.Lipid Droplets: A Key Cellular Organelle Associated with Cancer Cell Survival under Normoxia and HypoxiaIdentification and physiological characterization of phosphatidic acid phosphatase enzymes involved in triacylglycerol biosynthesis in Streptomyces coelicolorSexually dimorphic genome-wide binding of retinoid X receptor alpha (RXRα) determines male-female differences in the expression of hepatic lipid processing genes in miceLipin 2 binds phosphatidic acid by the electrostatic hydrogen bond switch mechanism independent of phosphorylation.Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver.Relationship of glucose and oleate metabolism to cardiac function in lipin-1 deficient (fld) miceA hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the ratDual function lipin proteins and glycerolipid metabolismLipin proteins form homo- and hetero-oligomersA phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesisLPIN1 deficiency with severe recurrent rhabdomyolysis and persistent elevation of creatine kinase levels due to chromosome 2 maternal isodisomy.Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms.Cross-talk phosphorylations by protein kinase C and Pho85p-Pho80p protein kinase regulate Pah1p phosphatidate phosphatase abundance in Saccharomyces cerevisiae.Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-null mice: suppression of lipin-1 and -2 in the glycerol-3-phosphate pathwayPhosphorylation of phosphatidate phosphatase regulates its membrane association and physiological functions in Saccharomyces cerevisiae: identification of SER(602), THR(723), AND SER(744) as the sites phosphorylated by CDC28 (CDK1)-encoded cyclin-deLipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation.The discovery of the fat-regulating phosphatidic acid phosphatase geneLiver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in miceMammalian triacylglycerol metabolism: synthesis, lipolysis, and signalingNew discoveries in CRMO: IL-1β, the neutrophil, and the microbiome implicated in disease pathogenesis in Pstpip2-deficient mice.Lipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor γ (PPARγ) gene expression during adipogenesis.Fluorescence spectroscopy measures yeast PAH1-encoded phosphatidate phosphatase interaction with liposome membranesMolecular mechanisms in genetically defined autoinflammatory diseases: disorders of amplified danger signaling.Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.Altered Lipid Synthesis by Lack of Yeast Pah1 Phosphatidate Phosphatase Reduces Chronological Life Span.Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expressionOntogenetic Expression of Lpin2 and Lpin3 Genes and Their Associations with Traits in Two Breeds of Chinese Fat-tailed SheepCurrent understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitisEfficacy of anti-IL-1 treatment in Majeed syndromeLipin1 regulates PPARγ transcriptional activity.Lipins: multifunctional lipid metabolism proteinsRedundant roles of the phosphatidate phosphatase family in triacylglycerol synthesis in human adipocytesMonogenic autoinflammatory diseases: disorders of amplified danger sensing and cytokine dysregulation.Cyclin-dependent kinase activity enhances phosphatidylcholine biosynthesis in Arabidopsis by repressing phosphatidic acid phosphohydrolase activity.Lipin-1 and lipin-3 together determine adiposity in vivo.
P2860
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P2860
A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2
description
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2009
@ast
im Oktober 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/10/23)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/10/23)
@nl
наукова стаття, опублікована в жовтні 2009
@uk
name
A conserved serine residue is ...... nctions of lipin-1 and lipin-2
@ast
A conserved serine residue is ...... nctions of lipin-1 and lipin-2
@en
A conserved serine residue is ...... nctions of lipin-1 and lipin-2
@nl
type
label
A conserved serine residue is ...... nctions of lipin-1 and lipin-2
@ast
A conserved serine residue is ...... nctions of lipin-1 and lipin-2
@en
A conserved serine residue is ...... nctions of lipin-1 and lipin-2
@nl
prefLabel
A conserved serine residue is ...... nctions of lipin-1 and lipin-2
@ast
A conserved serine residue is ...... nctions of lipin-1 and lipin-2
@en
A conserved serine residue is ...... nctions of lipin-1 and lipin-2
@nl
P2093
P2860
P3181
P356
P1476
A conserved serine residue is ...... nctions of lipin-1 and lipin-2
@en
P2093
Bernard P. C. Kok
David N. Brindley
Jay Dewald
Jimmy Donkor
Lauren O'Loughlin
Peixiang Zhang
Samantha Wong
P2860
P304
29968–29978
P3181
P356
10.1074/JBC.M109.023663
P407
P50
P577
2009-10-23T00:00:00Z