about
PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancersPim1 kinase synergizes with c-MYC to induce advanced prostate carcinomaEnhancement of myocardial regeneration through genetic engineering of cardiac progenitor cells expressing Pim-1 kinaseTargeting the Pim kinases in multiple myelomaA small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomasTargeting Pim kinases for cancer treatment: opportunities and challengesThe PIM kinases in hematological cancersConditional transgenic expression of PIM1 kinase in prostate induces inflammation-dependent neoplasiaPim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity.Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes.Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression.Cell and gene therapy for severe heart failure patients: the time and place for Pim-1 kinase.Covalent crosslinking of tumor antigens stimulates an antitumor immune response.Activation of cell cycle arrest and apoptosis by the proto-oncogene Pim-2.Preservation of myocardial structure is enhanced by pim-1 engineering of bone marrow cellsTrichomonosis, a common curable STI, and prostate carcinogenesis--a proposed molecular mechanism.The Pim protein kinases regulate energy metabolism and cell growthMetabolic dysfunction consistent with premature aging results from deletion of Pim kinasesThe over-expression of Pim-2 promote the tumorigenesis of prostatic carcinoma through phosphorylating eIF4B.Nucleostemin rejuvenates cardiac progenitor cells and antagonizes myocardial aging.Pim-1 kinase phosphorylates and stabilizes 130 kDa FLT3 and promotes aberrant STAT5 signaling in acute myeloid leukemia with FLT3 internal tandem duplicationFrontier of epilepsy research - mTOR signaling pathway.Cardiac progenitor cell cycling stimulated by pim-1 kinasePIM kinase inhibitor AZD1208 for treatment of MYC-driven prostate cancerA regulatory feedback loop between HIF-1α and PIM2 in HepG2 cellsPim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells.Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma.Functional Effect of Pim1 Depends upon Intracellular Localization in Human Cardiac Progenitor Cells.Inhibition of DNA methyltransferase as a novel therapeutic strategy to overcome acquired resistance to dual PI3K/mTOR inhibitors.IL-6 stimulates STAT3 and Pim-1 kinase in pancreatic cancer cell lines.FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expressionDifferential regulation of androgen receptor by PIM-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases.Increased mitotic rate coincident with transient telomere lengthening resulting from pim-1 overexpression in cardiac progenitor cells.Combination of Pim kinase inhibitors and Bcl-2 antagonists in chronic lymphocytic leukemia cellsPim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload.Functional role and therapeutic potential of the pim-1 kinase in colon carcinoma.eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants.PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis.Regulation of cardiac nitric oxide signaling by nuclear β-adrenergic and endothelin receptors.Nuclear β-adrenergic receptors modulate gene expression in adult rat heart.
P2860
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P248
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P2860
description
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im August 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/08/14)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/08/14)
@nl
наукова стаття, опублікована в серпні 2008
@uk
مقالة علمية (نشرت في 14-8-2008)
@ar
name
Pim kinase-dependent inhibition of c-Myc degradation
@ast
Pim kinase-dependent inhibition of c-Myc degradation
@en
Pim kinase-dependent inhibition of c-Myc degradation
@nl
type
label
Pim kinase-dependent inhibition of c-Myc degradation
@ast
Pim kinase-dependent inhibition of c-Myc degradation
@en
Pim kinase-dependent inhibition of c-Myc degradation
@nl
prefLabel
Pim kinase-dependent inhibition of c-Myc degradation
@ast
Pim kinase-dependent inhibition of c-Myc degradation
@en
Pim kinase-dependent inhibition of c-Myc degradation
@nl
P2093
P921
P3181
P356
P1433
P1476
Pim kinase-dependent inhibition of c-Myc degradation
@en
P2093
P2888
P304
P3181
P356
10.1038/ONC.2008.123
P407
P577
2008-08-14T00:00:00Z
P5875
P6179
1045120327