A heme export protein is required for red blood cell differentiation and iron homeostasis
about
The Fowler syndrome-associated protein FLVCR2 is an importer of hemeThe mitochondrial heme exporter FLVCR1b mediates erythroid differentiationKinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexinRegulation of cellular iron metabolismHepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic miceHuman iron-sulfur cluster assembly, cellular iron homeostasis, and diseaseC-terminal deletions in the ALAS2 gene lead to gain of function and cause X-linked dominant protoporphyria without anemia or iron overloadMolecular basis of inherited microcytic anemia due to defects in iron acquisition or heme synthesisFerroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulationIron Homeostasis in Health and DiseaseBiology of Heme in Mammalian Erythroid Cells and Related DisordersConcise review: stem cell-derived erythrocytes as upcoming players in blood transfusionManufacturing blood ex vivo: a futuristic approach to deal with the supply and safety concernsMurine mutants in the study of systemic iron metabolism and its disorders: an update on recent advancesMechanisms of mammalian iron homeostasisLack of Plasma Protein Hemopexin Results in Increased Duodenal Iron UptakeMice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in ErythropoiesisHeme dynamics and trafficking factors revealed by genetically encoded fluorescent heme sensors.Mutations in FLVCR2 are associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (Fowler syndrome)Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosaATP Binding Cassette Transporter Mediates Both Heme and Pesticide Detoxification in Tick Midgut CellsDelayed globin synthesis leads to excess heme and the macrocytic anemia of Diamond Blackfan anemia and del(5q) myelodysplastic syndromeTopologically conserved residues direct heme transport in HRG-1-related proteins.Autosomal recessive posterior column ataxia with retinitis pigmentosa caused by novel mutations in the FLVCR1 gene.Iron and porphyrin trafficking in heme biogenesis.Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen.Genome-wide analysis reveals novel genes essential for heme homeostasis in Caenorhabditis elegansLike iron in the blood of the people: the requirement for heme trafficking in iron metabolism.Prion Protein-Hemin Interaction Upregulates Hemoglobin Synthesis: Implications for Cerebral Hemorrhage and Sporadic Creutzfeldt-Jakob DiseaseControl of metazoan heme homeostasis by a conserved multidrug resistance protein.The physiological functions of iron regulatory proteins in iron homeostasis - an update.Targeting iron metabolism in drug discovery and deliveryRibosomopathies: human disorders of ribosome dysfunction.Two coregulated efflux transporters modulate intracellular heme and protoporphyrin IX availability in Streptococcus agalactiae.Iron overload in Plasmodium berghei-infected placenta as a pathogenesis mechanism of fetal death.Iron overload in sickle cell disease.Heme metabolism and erythropoiesis.Increased adipose tissue heme levels and exportation are associated with altered systemic glucose metabolism.Diamond Blackfan anemia 2008-2009: broadening the scope of ribosome biogenesis disorders.Heme-oxygenases during erythropoiesis in K562 and human bone marrow cells.
P2860
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P2860
A heme export protein is required for red blood cell differentiation and iron homeostasis
description
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Science
@fr
artículu científicu espublizáu en 2008
@ast
im Februar 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/02/08)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/02/08)
@nl
наукова стаття, опублікована в лютому 2008
@uk
name
A heme export protein is required for red blood cell differentiation and iron homeostasis
@ast
A heme export protein is required for red blood cell differentiation and iron homeostasis
@en
A heme export protein is required for red blood cell differentiation and iron homeostasis
@nl
type
label
A heme export protein is required for red blood cell differentiation and iron homeostasis
@ast
A heme export protein is required for red blood cell differentiation and iron homeostasis
@en
A heme export protein is required for red blood cell differentiation and iron homeostasis
@nl
prefLabel
A heme export protein is required for red blood cell differentiation and iron homeostasis
@ast
A heme export protein is required for red blood cell differentiation and iron homeostasis
@en
A heme export protein is required for red blood cell differentiation and iron homeostasis
@nl
P2093
P2860
P3181
P356
P1433
P1476
A heme export protein is required for red blood cell differentiation and iron homeostasis
@en
P2093
Ivana De Domenico
James Palis
Janis L Abkowitz
Jerry Kaplan
Michael B Vaughn
Paul D Kingsley
Raymond T Doty
Siobán B Keel
Sue Knoblaugh
P2860
P304
P3181
P356
10.1126/SCIENCE.1151133
P407
P577
2008-02-01T00:00:00Z