Tumor necrosis factor-alpha (TNF-alpha) regulates shedding of TNF-alpha receptor 1 by the metalloprotease-disintegrin ADAM8: evidence for a protease-regulated feedback loop in neuroprotection
about
ADAM8 as a drug target in pancreatic cancer.Tumor necrosis factor alpha has an early protective effect on retinal ganglion cells after optic nerve crush.N-glycosylation regulates ADAM8 processing and activationADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor proteinCellular prion protein regulates its own α-cleavage through ADAM8 in skeletal muscle.Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain.γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling.The ADAMs family of proteases as targets for the treatment of cancer.ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis.Inflammatory cytokines in experimental and human stroke.ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets.Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progression.Loss of vps54 function leads to vesicle traffic impairment, protein mis-sorting and embryonic lethality.Elevated levels of a disintegrin and metalloproteinase 8 in gingival crevicular fluid of patients with periodontal diseases.Effects of TNF receptor blockade on in vitro cell survival and response to negative energy balance in dairy cattle.The role of microglia in the progression of glaucomatous neurodegeneration- a review.Inducible expression of A Disintegrin and Metalloproteinase 8 in chronic periodontitis and gingival epithelial cells.Rsk2 controls synovial fibroblast hyperplasia and the course of arthritis.
P2860
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P2860
Tumor necrosis factor-alpha (TNF-alpha) regulates shedding of TNF-alpha receptor 1 by the metalloprotease-disintegrin ADAM8: evidence for a protease-regulated feedback loop in neuroprotection
description
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2010
@ast
im September 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/09/08)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/09/08)
@nl
наукова стаття, опублікована у вересні 2010
@uk
مقالة علمية (نشرت في 8-9-2010)
@ar
name
Tumor necrosis factor-alpha (T ...... edback loop in neuroprotection
@ast
Tumor necrosis factor-alpha (T ...... edback loop in neuroprotection
@en
Tumor necrosis factor-alpha (T ...... edback loop in neuroprotection
@nl
type
label
Tumor necrosis factor-alpha (T ...... edback loop in neuroprotection
@ast
Tumor necrosis factor-alpha (T ...... edback loop in neuroprotection
@en
Tumor necrosis factor-alpha (T ...... edback loop in neuroprotection
@nl
prefLabel
Tumor necrosis factor-alpha (T ...... edback loop in neuroprotection
@ast
Tumor necrosis factor-alpha (T ...... edback loop in neuroprotection
@en
Tumor necrosis factor-alpha (T ...... edback loop in neuroprotection
@nl
P2093
P921
P1476
Tumor necrosis factor-alpha (T ...... edback loop in neuroprotection
@en
P2093
Andrea Rittger
Dirk Wildeboer
Garrit Koller
Harald Jockusch
Jörg W Bartsch
Marcia L Moss
Silvia Naus
Yuji Minai
P304
12210-12218
P356
10.1523/JNEUROSCI.1520-10.2010
P407
P577
2010-09-01T00:00:00Z