Hedgehog signalling in the mouse requires intraflagellar transport proteins
about
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and functionThe dynamic cilium in human diseasesThe Small GTPase Rsg1 is important for the cytoplasmic localization and axonemal dynamics of intraflagellar transport proteinsLive imaging of individual cell divisions in mouse neuroepithelium shows asymmetry in cilium formation and Sonic hedgehog responseEvc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleusExome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signalingBBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypesMapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathwaysThe spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesisRAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesityMNS1 is essential for spermiogenesis and motile ciliary functions in miceThe Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesisThe Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formationNovel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomaliesThe hedgehog receptor patched is involved in cholesterol transportDefects in the IFT-B component IFT172 cause Jeune and Mainzer-Saldino syndromes in humansPitchfork regulates primary cilia disassembly and left-right asymmetryMice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic developmentLoss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transportThe output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteinsJoubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegansDisruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndromeArsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathwayThe role of primary cilia in neuronal functionThe Hedgehog gene family of the cnidarian, Nematostella vectensis, and implications for understanding metazoan Hedgehog pathway evolutionCharacterization of mouse IFT complex BHuman-specific modulation of transcriptional activity provided by endogenous retroviral insertionsTransient ciliogenesis involving Bardet-Biedl syndrome proteins is a fundamental characteristic of adipogenic differentiationCEP290 mutations are frequently identified in the oculo-renal form of Joubert syndrome-related disordersCilia and the cell cycle?The Meckel-Gruber syndrome gene, MKS3, is mutated in Joubert syndromeCiliogenesis and the DNA damage response: a stressful relationshipDifferential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date reviewCilia in autophagy and cancerCurrent topics of functional links between primary cilia and cell cycleSpecialized Cilia in Mammalian Sensory SystemsIns and outs of GPCR signaling in primary ciliaHedgehog Signaling in the Maintenance of Cancer Stem CellsCilia in vertebrate development and diseaseCilia functions in development
P2860
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P2860
Hedgehog signalling in the mouse requires intraflagellar transport proteins
description
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 2003
@ast
scientific journal article
@en
vedecký článok (publikovaný 2003/11/06)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/11/06)
@nl
наукова стаття, опублікована в листопаді 2003
@uk
مقالة علمية (نشرت في 6-11-2003)
@ar
name
Hedgehog signalling in the mouse requires intraflagellar transport proteins
@ast
Hedgehog signalling in the mouse requires intraflagellar transport proteins
@en
Hedgehog signalling in the mouse requires intraflagellar transport proteins
@nl
type
label
Hedgehog signalling in the mouse requires intraflagellar transport proteins
@ast
Hedgehog signalling in the mouse requires intraflagellar transport proteins
@en
Hedgehog signalling in the mouse requires intraflagellar transport proteins
@nl
prefLabel
Hedgehog signalling in the mouse requires intraflagellar transport proteins
@ast
Hedgehog signalling in the mouse requires intraflagellar transport proteins
@en
Hedgehog signalling in the mouse requires intraflagellar transport proteins
@nl
P2093
P50
P3181
P356
P1433
P1476
Hedgehog signalling in the mouse requires intraflagellar transport proteins
@en
P2093
Andrew S Rakeman
Noel S Murcia
P2888
P3181
P356
10.1038/NATURE02061
P407
P577
2003-11-01T00:00:00Z
P6179
1048084015