Eyes absent represents a class of protein tyrosine phosphatases
about
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisionsDephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absentBiochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutationsChronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamicsThe retinal determination gene network: from developmental regulator to cancer therapeutic targetMultiple Functions of the Eya Phosphotyrosine PhosphataseCrystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factorStructure-function analyses of the human SIX1–EYA2 complex reveal insights into metastasis and BOR syndromeEvolutionary and Structural Analyses of Mammalian Haloacid Dehalogenase-type Phosphatases AUM and Chronophin Provide Insight into the Basis of Their Different Substrate SpecificitiesTranscriptional regulation of cranial sensory placode developmentThe DACH/EYA/SIX gene network and its role in tumor initiation and progressionThe EYA tyrosine phosphatase activity is pro-angiogenic and is inhibited by benzbromaroneEya 1 acts as a critical regulator for specifying the metanephric mesenchymeSipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial developmentStructure-activity relationships of benzbromarone metabolites and derivatives as EYA inhibitory anti-angiogenic agentsEya4-deficient mice are a model for heritable otitis media.Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.Exome Sequencing Identifies a Mutation in EYA4 as a Novel Cause of Autosomal Dominant Non-Syndromic Hearing Loss.In vitro characterization of the Bacillus subtilis protein tyrosine phosphatase YwqEEvolutionary radiation pattern of novel protein phosphatases revealed by analysis of protein data from the completely sequenced genomes of humans, green algae, and higher plants.Pleiotropic effects in Eya3 knockout mice.Genetic regulation of pituitary gland development in human and mouseInhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis.The retinal determination gene eyes absent is regulated by the EGF receptor pathway throughout development in Drosophila.EYA1 mutations associated with the branchio-oto-renal syndrome result in defective otic development in Xenopus laevisLow-molecular-weight protein tyrosine phosphatases of Bacillus subtilis.The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration, and invasion of tumor cellsA phosphotyrosine switch determines the antitumor activity of ERβ.Structure and catalytic mechanism of human protein tyrosine phosphatome.VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX.Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity.Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motifMutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss.Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung.MAPK target sites of eyes absent are not required for eye development or survival in DrosophilaUsing Drosophila to decipher how mutations associated with human branchio-oto-renal syndrome and optical defects compromise the protein tyrosine phosphatase and transcriptional functions of eyes absentGenome-wide identification of direct targets of the Drosophila retinal determination protein Eyeless.Eyes absent tyrosine phosphatase activity is not required for Drosophila development or survivalThe PI3K/Akt signal hyperactivates Eya1 via the SUMOylation pathway.Targeting protein tyrosine phosphatases for anticancer drug discovery.
P2860
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P248
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P2860
Eyes absent represents a class of protein tyrosine phosphatases
description
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 2003
@ast
scientific journal article
@en
vedecký článok (publikovaný 2003/11/20)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/11/20)
@nl
наукова стаття, опублікована в листопаді 2003
@uk
مقالة علمية (نشرت في 20-11-2003)
@ar
name
Eyes absent represents a class of protein tyrosine phosphatases
@ast
Eyes absent represents a class of protein tyrosine phosphatases
@en
Eyes absent represents a class of protein tyrosine phosphatases
@nl
type
label
Eyes absent represents a class of protein tyrosine phosphatases
@ast
Eyes absent represents a class of protein tyrosine phosphatases
@en
Eyes absent represents a class of protein tyrosine phosphatases
@nl
prefLabel
Eyes absent represents a class of protein tyrosine phosphatases
@ast
Eyes absent represents a class of protein tyrosine phosphatases
@en
Eyes absent represents a class of protein tyrosine phosphatases
@nl
P2093
P921
P3181
P356
P1433
P1476
Eyes absent represents a class of protein tyrosine phosphatases
@en
P2093
Brian D Steinmetz
Chandramohan Kattamuri
Edwin J Ostrin
Graeme Mardon
Jayanagendra P Rayapureddi
Rashmi S Hegde
P2888
P304
P3181
P356
10.1038/NATURE02093
P407
P577
2003-11-01T00:00:00Z
P5875
P6179
1034456027