MeCP2 deficiency in Rett syndrome causes epigenetic aberrations at the PWS/AS imprinting center that affects UBE3A expression
about
Maternal disruption of Ube3a leads to increased expression of Ube3a-ATS in trans.The comorbidity of autism with the genomic disorders of chromosome 15q11.2-q13The ubiquitin proteasome system in neuropathologyThe odyssey of MeCP2 and parental imprintingDLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disordersDNA modifications: function and applications in normal and disease StatesAbnormalities of the DNA methylation mark and its machinery: an emerging cause of neurologic dysfunctionGenetic modifiers of MeCP2 function in Drosophila.Mecp2-null mice provide new neuronal targets for Rett syndrome.CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain FunctionPre-administration of G9a/GLP inhibitor during synaptogenesis prevents postnatal ethanol-induced LTP deficits and neurobehavioral abnormalities in adult mice.Synaptic determinants of rett syndrome.Truncation of Ube3a-ATS unsilences paternal Ube3a and ameliorates behavioral defects in the Angelman syndrome mouse modelCB1-receptor knockout neonatal mice are protected against ethanol-induced impairments of DNMT1, DNMT3A, and DNA methylation.Ethanol exposure induces neonatal neurodegeneration by enhancing CB1R Exon1 histone H4K8 acetylation and up-regulating CB1R function causing neurobehavioral abnormalities in adult mice.Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2.Dynamic changes in Histone H3 lysine 9 acetylation localization patterns during neuronal maturation require MeCP2.Increased copy number for methylated maternal 15q duplications leads to changes in gene and protein expression in human cortical samplesMechanisms of activation of the paternally expressed genes by the Prader-Willi imprinting center in the Prader-Willi/Angelman syndromes domains.Adult Phenotypes in Angelman- and Rett-Like Syndromes.Ube3a-ATS is an atypical RNA polymerase II transcript that represses the paternal expression of Ube3aNon-Coding RNAs at the Gnas and Snrpn-Ube3a Imprinted Gene Loci and Their Involvement in Hereditary Disorders.How imprinting centres work.Imprinting in neurons.Intracytoplasmic sperm injection--an assisted reproduction technique that should make us cautious about imprinting deregulation.X-linked mental retardation and epigenetics.G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain.Advances in behavioral genetics: mouse models of autism.MECP2 genomic structure and function: insights from ENCODESmchd1 regulates a subset of autosomal genes subject to monoallelic expression in addition to being critical for X inactivationUbe3a mRNA and protein expression are not decreased in Mecp2R168X mutant miceCell cloning-based transcriptome analysis in Rett patients: relevance to the pathogenesis of Rett syndrome of new human MeCP2 target genes.Genes related to mitochondrial functions, protein degradation, and chromatin folding are differentially expressed in lymphomonocytes of Rett syndrome patientsEthanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice.Evolving role of MeCP2 in Rett syndrome and autism.Genetic and epigenetic dysregulation of imprinted genes in the brain.Autism spectrum disorders: the quest for genetic syndromes.E6AP in the brain: one protein, dual function, multiple diseases.The contribution of epigenetics to understanding genetic factors in autism.
P2860
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P2860
MeCP2 deficiency in Rett syndrome causes epigenetic aberrations at the PWS/AS imprinting center that affects UBE3A expression
description
2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im April 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/04/15)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/04/15)
@nl
наукова стаття, опублікована у квітні 2005
@uk
مقالة علمية (نشرت في 15-4-2005)
@ar
name
MeCP2 deficiency in Rett syndr ...... that affects UBE3A expression
@ast
MeCP2 deficiency in Rett syndr ...... that affects UBE3A expression
@en
MeCP2 deficiency in Rett syndr ...... that affects UBE3A expression
@nl
type
label
MeCP2 deficiency in Rett syndr ...... that affects UBE3A expression
@ast
MeCP2 deficiency in Rett syndr ...... that affects UBE3A expression
@en
MeCP2 deficiency in Rett syndr ...... that affects UBE3A expression
@nl
prefLabel
MeCP2 deficiency in Rett syndr ...... that affects UBE3A expression
@ast
MeCP2 deficiency in Rett syndr ...... that affects UBE3A expression
@en
MeCP2 deficiency in Rett syndr ...... that affects UBE3A expression
@nl
P2093
P356
P1476
MeCP2 deficiency in Rett syndr ...... that affects UBE3A expression
@en
P2093
Aharon Razin
Kirill Makedonski
Liron Abuhatzira
Ruth Shemer
Yotam Kaufman
P304
P356
10.1093/HMG/DDI097
P577
2005-04-15T00:00:00Z