Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice - Wikidata - wikimedia - TriplyDB

Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice

Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice

http://www.wikidata.org/entity/Q28593469

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RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites An alternative form of replication protein a prevents viral replication in vitro A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression Modeling the study of DNA damage responses in mice Double-strand break repair on sex chromosomes: challenges during male meiotic prophase Replication protein A prevents promiscuous annealing between short sequence homologies: Implications for genome integrity Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity DNA damage response genes and the development of cancer metastasis Increased RPA1 gene dosage affects genomic stability potentially contributing to 17p13.3 duplication syndrome MEIOB exhibits single-stranded DNA-binding and exonuclease activities and is essential for meiotic recombination BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer RPA and PCNA suppress formation of large deletion errors by yeast DNA polymerase delta.Screening of differential expression genes in bone marrow cells of radon-exposed mice.Regulatory functions of the N-terminal domain of the 70-kDa subunit of replication protein A (RPA)Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.Replication protein A (AtRPA1a) is required for class I crossover formation but is dispensable for meiotic DNA break repair.The multi-replication protein A (RPA) system--a new perspective.Hyperphosphorylation of replication protein A in cisplatin-resistant and -sensitive head and neck squamous cell carcinoma cell lines Functional characterization of a cancer causing mutation in human replication protein A Cis lethal genetic interactions attenuate and alter p53 tumorigenesis.Network-based Identification of novel cancer genes.Interactive Roles of DNA Helicases and Translocases with the Single-Stranded DNA Binding Protein RPA in Nucleic Acid Metabolism.Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae Replication stress induces micronuclei comprising of aggregated DNA double-strand breaks Repair-specific functions of replication protein A.Role of replication protein A as sensor in activation of the S-phase checkpoint in Xenopus egg extracts.The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers.A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening.DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair In vitro analysis of the role of replication protein A (RPA) and RPA phosphorylation in ATR-mediated checkpoint signaling Elevated level of human RPA interacting protein α (hRIPα) in cervical tumor cells is involved in cell proliferation through regulating RPA transport.Replication protein A: single-stranded DNA's first responder: dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair.RPA coordinates DNA end resection and prevents formation of DNA hairpins.RPA antagonizes microhomology-mediated repair of DNA double-strand breaks.Double-strand breaks in the myotonic dystrophy type 1 and the fragile X syndrome triplet repeat sequences induce different types of mutations in DNA flanking sequences in Escherichia coli.RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling.Oxidative Damage to RPA Limits the Nucleotide Excision Repair Capacity of Human Cells Whole genomes redefine the mutational landscape of pancreatic cancer.Structure-Based Analysis Reveals Cancer Missense Mutations Target Protein Interaction Interfaces

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Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice

http://www.wikidata.org/entity/Q28593469

description

2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2005 թվականի հուլիսին հրատարակված գիտական հոդված

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articolo scientifico

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artículu científicu espublizáu en 2005

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im Juli 2005 veröffentlichter wissenschaftlicher Artikel

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scientific journal article

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vedecký článok (publikovaný 2005/07/01)

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vědecký článek publikovaný v roce 2005

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wetenschappelijk artikel (gepubliceerd op 2005/07/01)

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наукова стаття, опублікована в липні 2005

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name

Mutation in Rpa1 results in de ...... instability and cancer in mice

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Mutation in Rpa1 results in de ...... instability and cancer in mice

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Mutation in Rpa1 results in de ...... instability and cancer in mice

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Mutation in Rpa1 results in de ...... instability and cancer in mice

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Mutation in Rpa1 results in de ...... instability and cancer in mice

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Mutation in Rpa1 results in de ...... instability and cancer in mice

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Nature Genetics

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Mutation in Rpa1 results in de ...... instability and cancer in mice

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Christopher D. Putnam

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Danaise V. Carrión

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Lisa Edelmann

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Michael F. Kane

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Raju Kucherlapati

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Richard D. Kolodner

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Robert Russell

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Weijia Zhang

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Winfried Edelmann

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Yuxun Wang

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

Multifunctional yeast high-copy-number shuttle vectors

Chromosomal stability and the DNA double-stranded break connection

High-resolution genomic mapping of the three human replication protein A genes (RPA1, RPA2, and RPA3)

Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism

Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas

Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage

Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair

A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice

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750–755

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scholarly article

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2500802

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10.1038/NG1587

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7

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37

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2005-07-01T00:00:00Z

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7778843

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15965476

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Replication protein A1