Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism
about
Genetic and epigenetic changes in sporadic endocrine tumors: parathyroid tumorsMutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cellsMenin determines K-RAS proliferative outputs in endocrine cellsMice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndromeClinical and molecular genetics of parathyroid neoplasmsMouse models of endocrine tumours.Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in miceParathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion.Osteoblast menin regulates bone mass in vivo.Exploring the tumors of multiple endocrine neoplasia type 1 in mouse models for basic and preclinical studiesParathyroid tumor development involves deregulation of homeobox genesMenin represses tumorigenesis via repressing cell proliferation.Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.The Cell Death Inhibitor ARC Is Induced in a Tissue-Specific Manner by Deletion of the Tumor Suppressor Gene Men1, but Not Required for Tumor Development and Growth.Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation.Insulinoma: pathophysiology, localization and managementThe extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development.Diphtheria Toxin- and GFP-Based Mouse Models of Acquired Hypoparathyroidism and Treatment With a Long-Acting Parathyroid Hormone Analog.Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis.Parathyroid-specific interaction of the calcium-sensing receptor and G alpha q.Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.MAJOR MOLECULAR GENETIC DRIVERS IN SPORADIC PRIMARY HYPERPARATHYROIDISM.Persistent fibroblast growth factor 23 signalling in the parathyroid glands for secondary hyperparathyroidism in mice with chronic kidney disease.Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse.Parathyroid diseases and animal models.A MEN1 pancreatic neuroendocrine tumour mouse model under temporal control.The future: genetics advances in MEN1 therapeutic approaches and management strategies.Two nonsense somatic mutations in MEN1 identified in sporadic insulinomas.Diagnosis, management, histology and genetics of sporadic primary hyperparathyroidism: old knowledge with new tricks.Interrelated role of Klotho and calcium-sensing receptor in parathyroid hormone synthesis and parathyroid hyperplasia.Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System
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P2860
Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism
description
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im November 2003 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2003/11/15)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/11/15)
@nl
наукова стаття, опублікована в листопаді 2003
@uk
مقالة علمية (نشرت في 15-11-2003)
@ar
name
Parathyroid gland-specific del ...... ercalcemic hyperparathyroidism
@ast
Parathyroid gland-specific del ...... ercalcemic hyperparathyroidism
@en
Parathyroid gland-specific del ...... ercalcemic hyperparathyroidism
@nl
type
label
Parathyroid gland-specific del ...... ercalcemic hyperparathyroidism
@ast
Parathyroid gland-specific del ...... ercalcemic hyperparathyroidism
@en
Parathyroid gland-specific del ...... ercalcemic hyperparathyroidism
@nl
prefLabel
Parathyroid gland-specific del ...... ercalcemic hyperparathyroidism
@ast
Parathyroid gland-specific del ...... ercalcemic hyperparathyroidism
@en
Parathyroid gland-specific del ...... ercalcemic hyperparathyroidism
@nl
P2093
P1433
P1476
Parathyroid gland-specific del ...... ercalcemic hyperparathyroidism
@en
P2093
A Lee Burns
Alan Remaley
Allen M Spiegel
Andrew Arnold
Chiara Mazzanti
Dominique Lorang
Ewa Turner
Francis S Collins
H Richard Alexander
Jerrold M Ward
P304
P407
P577
2003-11-01T00:00:00Z