MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
about
The nuclear envelopathies and human diseasesImpairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomasSIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activityCrystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpointInhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisonsSimian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1FAT10 plays a role in the regulation of chromosomal stabilityThe CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cellsNEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signalingMAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiationCentromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome lossSpatiotemporal control of mitosis by the conserved spindle matrix protein MegatorIdentification of a MAD2-binding protein, CMT2, and its role in mitosis.Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint controlMTBP plays a crucial role in mitotic progression and chromosome segregationSil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpointMad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint.Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cellsLoading and unloading: orchestrating centrosome duplication and spindle assembly by Ran/Crm1Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complexA requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpointDeficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stressConformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpointLethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.Chromosomal instability and cancer: a complex relationship with therapeutic potentialThe role of aneuploidy in promoting and suppressing tumorsMitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint.Kinetochore dynein is required for chromosome motion and congression independent of the spindle checkpointWhen 2+2=5: the origins and fates of aneuploid and tetraploid cellsEpigenetic inactivation of CHFR in human tumorsDido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stabilityMad2 overexpression promotes aneuploidy and tumorigenesis in miceGenetic variability in MCF-7 sublines: evidence of rapid genomic and RNA expression profile modificationsCell cycle and centromere FISH studies in premature centromere division.BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolutionInsights into APC/C: from cellular function to diseases and therapeuticsConnecting the speckles: Splicing kinases and their role in tumorigenesis and treatment responseDNA damage associated with mitosis and cytokinesis failureFunctional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesisMitotic and mitogenic Wnt signalling
P2860
Q21284427-C65DAF2F-5419-4EDC-9B55-076963FDB405Q24291921-C51AFA6A-D4F2-4F38-AE01-9E2B0F4212D1Q24294017-E6F3CF91-522D-4981-8F81-9A98DEFDE189Q24297170-72A0F14F-D1DB-4DFB-A7C7-FF66F4064EE3Q24301844-2712E442-E7D5-45EC-9D09-A3AD936551A1Q24305356-38677749-FDC6-434B-9B15-64176A8FC377Q24305422-154F9F78-B020-42D0-B571-770B29CE8740Q24305557-92FD9DD5-7275-4320-A64C-381ED0A788D7Q24310671-B6EE6575-9D1E-42B4-8C65-E8515B77613FQ24310703-84F2ACBA-D2FE-4B6B-B294-2795486626F6Q24316292-2442F60B-7017-40F0-8FED-254022B4E6A7Q24319051-1657A36B-DBC7-4915-BA48-4BDB5D06453DQ24321983-79D32893-54C7-47D7-951A-081B026A38FDQ24338299-997140A0-51A2-420B-920F-EED0519340FEQ24338557-7F358390-2D1E-45B2-B3EC-F8B05EB63CBDQ24530007-7DEBF955-7A7A-4EDC-8F5D-9680C1507AF5Q24534571-A3A453F7-654C-4233-9B05-1B7D267B51AEQ24537482-AEB51EFC-12BF-420B-B39A-AC47529969C8Q24540385-338630CC-F1E0-4A84-B742-56ADC13300C9Q24548359-135959BA-C66F-470D-8384-B8FB1161E4FBQ24558787-8BEBF8FB-32CD-4A4C-916D-55271EFA8322Q24559993-0FB8947D-3F7D-4C3E-B182-8E3555BAD3CFQ24563156-C4E6E95C-71E7-4DD2-B85F-F8F0E0E8ED28Q24564215-F5C747B0-F467-4EFD-902B-E79874F13ED7Q24608609-11F3C501-6EEA-4218-8EBC-584053A0DD85Q24648182-6C82598C-3217-4C5D-8F37-9532487F0E98Q24648791-5CD72FE0-A778-439A-8627-617E3A1AB44AQ24649800-AA89A0A3-185D-4FCA-8E14-B11435A9D491Q24658364-420C4A2A-ABB0-400E-9ED2-09C1D1DD4CAAQ24670147-2AF223CD-9BF4-4944-9A53-CE3D5F67BB73Q24682740-FA68938D-4B0A-494E-BD6B-E284215DA963Q24684680-35202917-05E4-445F-B470-D16167F94D8FQ24800072-0E905172-3DB1-41D6-A266-9CF3A9BC6F7DQ24814610-5DB04FEF-B780-4086-AB05-C65C962A12BDQ25255829-DC3D088A-F485-4674-B9BF-2270515AC53FQ26740196-82DDF277-D02F-40B9-B718-B29628E62FB7Q26824298-BF01E834-EC85-4B65-B2E9-E8DD1B742F2FQ26991874-0278D687-7AB3-4C5E-95FE-B1D267EA954BQ26998944-ADB8E9E9-0552-4F89-98B4-8008D4165D2DQ27021818-2E02A15D-1782-4C2D-B585-BC56249661BE
P2860
MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
description
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 2001
@ast
scientific journal article
@en
vedecký článok (publikovaný 2001/01/18)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/01/18)
@nl
наукова стаття, опублікована в січні 2001
@uk
مقالة علمية (نشرت في 18-1-2001)
@ar
name
MAD2 haplo-insufficiency cause ...... instability in mammalian cells
@ast
MAD2 haplo-insufficiency cause ...... instability in mammalian cells
@en
MAD2 haplo-insufficiency cause ...... instability in mammalian cells
@nl
type
label
MAD2 haplo-insufficiency cause ...... instability in mammalian cells
@ast
MAD2 haplo-insufficiency cause ...... instability in mammalian cells
@en
MAD2 haplo-insufficiency cause ...... instability in mammalian cells
@nl
prefLabel
MAD2 haplo-insufficiency cause ...... instability in mammalian cells
@ast
MAD2 haplo-insufficiency cause ...... instability in mammalian cells
@en
MAD2 haplo-insufficiency cause ...... instability in mammalian cells
@nl
P2093
P3181
P356
P1433
P1476
MAD2 haplo-insufficiency cause ...... instability in mammalian cells
@en
P2093
A. Chatterjee
L. S. Michel
P. K. Sorger
R. Benezra
R. Kirchwegger
V. Liberal
V. V. Murty
P2888
P304
P3181
P356
10.1038/35053094
P407
P577
2001-01-18T00:00:00Z
P5875
P6179
1035074433