Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength
about
Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemiaNotch signaling in CD4 and CD8 T cell developmentNF-kB inhibitor blocks B cell development at two checkpointsExpression of the SNARE protein SNAP-23 is essential for cell survivalPresenilins regulate alphabeta T cell development by modulating TCR signalingc-Myb is required for pro-B cell differentiation.Myristoylation: An Important Protein Modification in the Immune ResponseHIV-1 Rev-binding protein accelerates cellular uptake of iron to drive Notch-induced T cell leukemogenesis in miceThe notch intracellular domain can function as a coactivator for LEF-1Notch dimerization is required for leukemogenesis and T-cell development.Notch signalling inhibits CD4 expression during initiation and differentiation of human T cell lineage.Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 bindingLymphostromal interactions in thymic development and function.Optimal T-cell receptor affinity for inducing autoimmunity.Fli-1 overexpression in hematopoietic progenitors deregulates T cell development and induces pre-T cell lymphoblastic leukaemia/lymphoma.Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.The role of Notch signaling during hematopoietic lineage commitment.Notch signaling in hematopoiesis and early lymphocyte development.PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ TregsCell of origin strongly influences genetic selection in a mouse model of T-ALLLKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation.Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cellsEstablishment and functioning of intrathymic microenvironments.Regulation of intrathymic T-cell development by Lunatic Fringe- Notch1 interactions.Recent insights into the signals that control alphabeta/gammadelta-lineage fate.Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cellsMaintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactionsNotch signaling in T-cell acute lymphoblastic leukemia.The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development.X-ray irradiation selectively kills thymocytes of different stages and impairs the maturation of donor-derived CD4(+)CD8(+) thymocytes in recipient thymus.NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL.Activated Notch2 potentiates CD8 lineage maturation and promotes the selective development of B1 B cells.Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for NotchThe proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasisIkaros controls isotype selection during immunoglobulin class switch recombination.Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals.Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4(+) T Cells.Notch signaling: switching an oncogene to a tumor suppressor.miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism.
P2860
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P2860
Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength
description
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im März 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/03/01)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/03/01)
@nl
наукова стаття, опублікована в березні 2001
@uk
مقالة علمية (نشرت في مارس 2001)
@ar
name
Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength
@ast
Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength
@en
Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength
@nl
type
label
Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength
@ast
Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength
@en
Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength
@nl
prefLabel
Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength
@ast
Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength
@en
Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength
@nl
P2093
P1433
P1476
Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength
@en
P2093
D. J. Izon
F. G. Karnell
G. A. Koretzky
J. A. Punt
N. J. Boerth
P. S. Myung
W. S. Pear
P304
P356
10.1016/S1074-7613(01)00107-8
P407
P577
2001-03-01T00:00:00Z