Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1,N6-ethenoadenine and hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanine
about
Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damageDNA glycosylases: in DNA repair and beyondAag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1DNA bending and a flip-out mechanism for base excision by the helix–hairpin–helix DNA glycosylase, Escherichia coli AlkANon-productive DNA damage binding by DNA glycosylase-like protein Mag2 from Schizosaccharomyces pombeDissecting the broad substrate specificity of human 3-methyladenine-DNA glycosylaseOxanine DNA glycosylase activity from Mammalian alkyladenine glycosylaseDifferential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylaseHighly efficient base excision repair (BER) in human and rat male germ cellsIncision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease VA 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatchRecognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG).Recent progress in the biology, chemistry and structural biology of DNA glycosylases.Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate.Overexpression of enzymes that repair endogenous damage to DNA.An invariant aspartic acid in the DNA glycosylase domain of DEMETER is necessary for transcriptional activation of the imprinted MEDEA gene.Human base excision repair creates a bias toward -1 frameshift mutationsTargeted deletion of mNth1 reveals a novel DNA repair enzyme activity.ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents.Structural insights by molecular dynamics simulations into differential repair efficiency for ethano-A versus etheno-A adducts by the human alkylpurine-DNA N-glycosylase.Highly mutagenic exocyclic DNA adducts are substrates for the human nucleotide incision repair pathway.Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta.A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas.Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patientsDNA repair is indispensable for survival after acute inflammation.Vinyl chloride-a classical industrial toxicant of new interest.3,N4-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase.Repair of Alkylation Damage in Eukaryotic Chromatin Depends on Searching Ability of Alkyladenine DNA Glycosylase.AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA.Base excision repair in physiology and pathology of the central nervous systemCadmium(II) inhibition of human uracil-DNA glycosylase by catalytic water supplantation.1,N(2)-ethenoguanine, a mutagenic DNA adduct, is a primary substrate of Escherichia coli mismatch-specific uracil-DNA glycosylase and human alkylpurine-DNA-N-glycosylase.The Escherichia coli 3-methyladenine DNA glycosylase AlkA has a remarkably versatile active site.The Saccharomyces cerevisiae ETH1 gene, an inducible homolog of exonuclease III that provides resistance to DNA-damaging agents and limits spontaneous mutagenesis.Interactions of the human, rat, Saccharomyces cerevisiae and Escherichia coli 3-methyladenine-DNA glycosylases with DNA containing dIMP residues.N-methylpurine DNA glycosylase plays a pivotal role in the threshold response of ethyl methanesulfonate-induced chromosome damage.Repair of damaged basesDirect repair of 3,N(4)-ethenocytosine by the human ALKBH2 dioxygenase is blocked by the AAG/MPG glycosylase.The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury.The effect of Msh2 knockdown on toxicity induced by tert-butyl-hydroperoxide, potassium bromate, and hydrogen peroxide in base excision repair proficient and deficient cells
P2860
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P2860
Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1,N6-ethenoadenine and hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanine
description
1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1997
@ast
im November 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/11/25)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/11/25)
@nl
наукова стаття, опублікована в листопаді 1997
@uk
name
Targeted deletion of alkylpuri ...... ethenocytosine or 8-oxoguanine
@ast
Targeted deletion of alkylpuri ...... ethenocytosine or 8-oxoguanine
@en
Targeted deletion of alkylpuri ...... ethenocytosine or 8-oxoguanine
@nl
type
label
Targeted deletion of alkylpuri ...... ethenocytosine or 8-oxoguanine
@ast
Targeted deletion of alkylpuri ...... ethenocytosine or 8-oxoguanine
@en
Targeted deletion of alkylpuri ...... ethenocytosine or 8-oxoguanine
@nl
prefLabel
Targeted deletion of alkylpuri ...... ethenocytosine or 8-oxoguanine
@ast
Targeted deletion of alkylpuri ...... ethenocytosine or 8-oxoguanine
@en
Targeted deletion of alkylpuri ...... ethenocytosine or 8-oxoguanine
@nl
P2093
P2860
P3181
P356
P1476
Targeted deletion of alkylpuri ...... ethenocytosine or 8-oxoguanine
@en
P2093
P2860
P304
12869-12874
P3181
P356
10.1073/PNAS.94.24.12869
P407
P577
1997-11-01T00:00:00Z