Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL
about
Increased dietary intake of vitamin A promotes aortic valve calcification in vivoCoordinating tissue interactions: Notch signaling in cardiac development and diseaseFibrocalcific aortic valve disease: opportunity to understand disease mechanisms using mouse modelsConserved transcriptional regulatory mechanisms in aortic valve development and diseaseIn vitro models of aortic valve calcification: solidifying a systemMolecular and cellular aspects of calcific aortic valve diseaseInhibitory role of Notch1 in calcific aortic valve diseaseThe congenital bicuspid aortic valve can experience high-frequency unsteady shear stresses on its leaflet surface.Embryonic Development of the Bicuspid Aortic Valve.Deficient signaling via Alk2 (Acvr1) leads to bicuspid aortic valve development.Advances in the treatment of aortic valve disease: is it time for companion diagnostics?Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease.Potential drug targets for calcific aortic valve disease.Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells.Animal models of calcific aortic valve diseaseInhibition of Notch1 signaling reduces abdominal aortic aneurysm in mice by attenuating macrophage-mediated inflammation.A roadmap to investigate the genetic basis of bicuspid aortic valve and its complications: insights from the International BAVCon (Bicuspid Aortic Valve Consortium).The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesisBicuspid aortic valve and thoracic aortic aneurysm: three patient populations, two disease phenotypes, and one shared genotype.Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis.Pathophysiology of valvular heart disease.The pathology and pathobiology of bicuspid aortic valve: State of the art and novel research perspectives.Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development.Therapeutic modulation of Notch signalling--are we there yet?Molecular biology of calcific aortic valve disease: towards new pharmacological therapies.Review of molecular and mechanical interactions in the aortic valve and aorta: implications for the shared pathogenesis of aortic valve disease and aortopathy.Notch signal integration in the vasculature during remodelingHeart Valve Biomechanics and Underlying MechanobiologyEndothelial nitric oxide signaling regulates Notch1 in aortic valve disease.Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: A critical role of the Notch1-NF-κB pathway in BMP-2 expressionDifferential activation of valvulogenic, chondrogenic, and osteogenic pathways in mouse models of myxomatous and calcific aortic valve disease.Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency.NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endotheliumNotch1 Mutation Leads to Valvular Calcification Through Enhanced Myofibroblast MechanotransductionCalcific Aortic Valve Disease: a Developmental Biology Perspective.Notch-Tnf signalling is required for development and homeostasis of arterial valves.Cross Talk between NOTCH Signaling and Biomechanics in Human Aortic Valve Disease Pathogenesis.Monocytes and Macrophages in Heart Valves: Uninvited Guests or Critical Performers?
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P2860
Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL
description
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2011
@ast
im Juli 2011 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2011/07/01)
@sk
vědecký článek publikovaný v roce 2011
@cs
wetenschappelijk artikel (gepubliceerd op 2011/07/01)
@nl
наукова стаття, опублікована в липні 2011
@uk
مقالة علمية (نشرت في يوليو 2011)
@ar
name
Diet-induced aortic valve dise ...... tch pathway effector RBPJK/CSL
@ast
Diet-induced aortic valve dise ...... tch pathway effector RBPJK/CSL
@en
Diet-induced aortic valve dise ...... tch pathway effector RBPJK/CSL
@nl
type
label
Diet-induced aortic valve dise ...... tch pathway effector RBPJK/CSL
@ast
Diet-induced aortic valve dise ...... tch pathway effector RBPJK/CSL
@en
Diet-induced aortic valve dise ...... tch pathway effector RBPJK/CSL
@nl
prefLabel
Diet-induced aortic valve dise ...... tch pathway effector RBPJK/CSL
@ast
Diet-induced aortic valve dise ...... tch pathway effector RBPJK/CSL
@en
Diet-induced aortic valve dise ...... tch pathway effector RBPJK/CSL
@nl
P2093
P921
P1476
Diet-induced aortic valve dise ...... tch pathway effector RBPJK/CSL
@en
P2093
Beatriz Martínez-Poveda
Donal MacGrogan
Francisco Fernández-Avilés
Javier Bermejo
Jesús C. Casanova
José Luis de la Pompa
Meritxell Nus
Yolanda Benito
P304
P356
10.1161/ATVBAHA.111.227561
P407
P577
2011-07-01T00:00:00Z