Transgenic replacement of type V adenylyl cyclase identifies a critical mechanism of beta-adrenergic receptor dysfunction in the G alpha q overexpressing mouse

Transgenic replacement of type V adenylyl cyclase identifies a critical mechanism of beta-adrenergic receptor dysfunction in the G alpha q overexpressing mouse

Item
http://www.wikidata.org/entity/Q28594652
An adenylyl cyclase-mAKAPbeta signaling complex regulates cAMP levels in cardiac myocytesA compartmentalized mathematical model of the β1-adrenergic signaling system in mouse ventricular myocytesBeta-adrenergic receptors in the failing heart: the good, the bad, and the unknown.Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of Galphaq protein-induced cardiomyopathyDisruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload.New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy.Type 5 adenylyl cyclase plays a major role in stabilizing heart rate in response to microgravity induced by parabolic flightModulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.Gene therapy in heart failure.Adenylyl cyclase type 5 in cardiac disease, metabolism, and aging.Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy.Gene and cell therapy for heart failure.Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway.Bitransgenesis with beta(2)-adrenergic receptors or adenylyl cyclase fails to improve beta(1)-adrenergic receptor cardiomyopathy.Unanticipated signaling events associated with cardiac adenylyl cyclase gene transfer.Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy.
P2860

Transgenic replacement of type V adenylyl cyclase identifies a critical mechanism of beta-adrenergic receptor dysfunction in the G alpha q overexpressing mouse

Item
http://www.wikidata.org/entity/Q28594652
description
1999 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1999
@ast
im September 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/09/17)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/09/17)
@nl
наукова стаття, опублікована у вересні 1999
@uk
مقالة علمية (نشرت في 17-9-1999)
@ar
name
Transgenic replacement of type ...... G alpha q overexpressing mouse
@ast
Transgenic replacement of type ...... G alpha q overexpressing mouse
@en
Transgenic replacement of type ...... G alpha q overexpressing mouse
@nl
type
label
Transgenic replacement of type ...... G alpha q overexpressing mouse
@ast
Transgenic replacement of type ...... G alpha q overexpressing mouse
@en
Transgenic replacement of type ...... G alpha q overexpressing mouse
@nl
prefLabel
Transgenic replacement of type ...... G alpha q overexpressing mouse
@ast
Transgenic replacement of type ...... G alpha q overexpressing mouse
@en
Transgenic replacement of type ...... G alpha q overexpressing mouse
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P921
P356
P1433
P1476
Transgenic replacement of type ...... G alpha q overexpressing mouse
@en
P2093
P304
P31
P356
10.1016/S0014-5793(99)01147-3
P407
P433
P478
P577
P698
P921