Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum
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beta-Amyloid degradation and Alzheimer's diseaseThe Kell protein of the common K2 phenotype is a catalytically active metalloprotease, whereas the rare Kell K1 antigen is inactive. Identification of novel substrates for the Kell proteinHuman endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizationsEndothelin-converting enzyme-like 1 (ECEL1) is present both in the plasma membrane and in the endoplasmic reticulumOrganization and chromosomal localization of the human ECEL1 (XCE) gene encoding a zinc metallopeptidase involved in the nervous control of respirationThe vascular endothelin system in hypertension--recent patents and discoveriesEndothelinEndothelin-converting enzymes and related metalloproteases in Alzheimer's diseaseNeutral endopeptidase inhibition and the natriuretic peptide system: an evolving strategy in cardiovascular therapeuticsA fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter molecular cloning and characterizationFGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralizationConstitutive phosphorylation of human endothelin-converting enzyme-1 isoformsHeterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloproteaseAlzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzymeEndothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12Endothelin-1 is synthesized and inhibits cyclic adenosine monophosphate- dependent anion secretion by an autocrine/paracrine mechanism in gallbladder epithelial cellsBiochemical and physical characterisation of urinary nanovesicles following CHAPS treatmentMolecular identification and characterization of novel membrane-bound metalloprotease, the soluble secreted form of which hydrolyzes a variety of vasoactive peptidesNeprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidasesNeonatal lethality in mice deficient in XCE, a novel member of the endothelin-converting enzyme and neutral endopeptidase familyDisruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac developmentInterleukin-1 mediates endothelin-1-induced fever and prostaglandin production in the preoptic area of ratsRat endothelin-converting enzyme-1 forms a dimer through Cys412 with a similar catalytic mechanism and a distinct substrate binding mechanism compared with neutral endopeptidase-24.11A three-dimensional model of the neprilysin 2 active site based on the X-ray structure of neprilysin. Identification of residues involved in substrate hydrolysis and inhibitor binding of neprilysin 2Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysinAnimals lacking endothelin-converting enzyme-2 are deficient in learning and memory.Alternative splicing regulates the endoplasmic reticulum localization or secretion of soluble secreted endopeptidase.Cyclic expression of endothelin-converting enzyme-1 mediates the functional regulation of seminiferous tubule contraction.Characterization of the c-specific promoter of the gene encoding human endothelin-converting enzyme-1 (ECE-1).Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.Dynamic changes in the secondary structure of ECE-1 and XCE account for their different substrate specificities.The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function.Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2Endothelins in health and disease: an overview.Secretory pathways in endothelin synthesis.Identification of an endothelin-converting enzyme-2-specific fluorigenic substrate and development of an in vitro and ex vivo enzymatic assayUnderstanding the basis of auriculocondylar syndrome: Insights from human, mouse and zebrafish genetic studies.Opioid receptor function is regulated by post-endocytic peptide processing.Endothelins in the urinary tract.BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension.
P2860
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P2860
Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum
description
1995 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1995
@ast
im Juni 1995 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1995/06/23)
@sk
vědecký článek publikovaný v roce 1995
@cs
wetenschappelijk artikel (gepubliceerd op 1995/06/23)
@nl
наукова стаття, опублікована в червні 1995
@uk
name
Endothelin-converting enzyme-2 ...... rotease with acidic pH optimum
@ast
Endothelin-converting enzyme-2 ...... rotease with acidic pH optimum
@en
Endothelin-converting enzyme-2 ...... rotease with acidic pH optimum
@nl
type
label
Endothelin-converting enzyme-2 ...... rotease with acidic pH optimum
@ast
Endothelin-converting enzyme-2 ...... rotease with acidic pH optimum
@en
Endothelin-converting enzyme-2 ...... rotease with acidic pH optimum
@nl
prefLabel
Endothelin-converting enzyme-2 ...... rotease with acidic pH optimum
@ast
Endothelin-converting enzyme-2 ...... rotease with acidic pH optimum
@en
Endothelin-converting enzyme-2 ...... rotease with acidic pH optimum
@nl
P3181
P356
P1476
Endothelin-converting enzyme-2 ...... rotease with acidic pH optimum
@en
P2093
M. Yanagisawa
P304
15262–15268
P3181
P356
10.1074/JBC.270.25.15262
P407
P577
1995-06-23T00:00:00Z