Mutational analysis of the regulatory mechanism of PKN: the regulatory region of PKN contains an arachidonic acid-sensitive autoinhibitory domain
about
The Rac1 polybasic region is required for interaction with its effector PRK1Single cell pattern formation and transient cytoskeletal arraysMolecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1)Association of immature hypophosphorylated protein kinase cepsilon with an anchoring protein CG-NAPMEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of an MAPK kinase kinasePKN regulates phospholipase D1 through direct interactionPyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDSRho GTPases and their effector proteinsDevelopment of an intracellularly acting inhibitory peptide selective for PKN.PKN binds and phosphorylates human papillomavirus E6 oncoprotein.Phosphorylation of tau is regulated by PKN.Disruption of the protein kinase N gene of drosophila melanogaster results in the recessive delorean allele (pkndln) with a negative impact on wing morphogenesisSite recognition and substrate screens for PKN family proteins.PKN delays mitotic timing by inhibition of Cdc25C: possible involvement of PKN in the regulation of cell division.Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway.Microneedle fractional radiofrequency increases epidermal hyaluronan and reverses age-related epidermal dysfunction.A rho-binding protein kinase C-like activity is required for the function of protein kinase N in Drosophila development.Identification of Highly Potent Protein Kinase C-Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing.Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors.Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion.Protein Kinase C-Related Kinase (PKN/PRK). Potential Key-Role for PKN1 in Protection of Hypoxic Neurons.Selective Hyaluronan-CD44 Signaling Promotes miRNA-21 Expression and Interacts with Vitamin D Function during Cutaneous Squamous Cell Carcinomas Progression Following UV IrradiationThe insert region of RhoA is essential for Rho kinase activation and cellular transformation.Identification of an interaction between the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor with protein kinase C-related kinase (PRK) 1: implications for prostate cancer.Involvement of protein kinase PKN1 in G2/M delay caused by arsenite.Impaired lymphocyte trafficking in mice deficient in the kinase activity of PKN1.Regulation of protein kinase C-related protein kinase 2 (PRK2) by an intermolecular PRK2-PRK2 interaction mediated by Its N-terminal domain.Selective matrix (hyaluronan) interaction with CD44 and RhoGTPase signaling promotes keratinocyte functions and overcomes age-related epidermal dysfunction.Hyaluronan-CD44 interaction with Rac1-dependent protein kinase N-gamma promotes phospholipase Cgamma1 activation, Ca(2+) signaling, and cortactin-cytoskeleton function leading to keratinocyte adhesion and differentiation.RHO GTPases activate PKNsPKN2 is essential for mouse embryonic development and proliferation of mouse fibroblasts.
P2860
Q24300612-24D35A25-A08F-4388-A1C7-6E39120FBC2EQ26851587-E209767D-688B-4E4B-A82E-DE4145E44FFCQ27642233-4DBF931A-5BEB-497C-9382-6BAEDB29725BQ28143906-F8344596-732F-49C6-9D6D-ABA75FAA8E5BQ28144745-6963FBA4-769A-4414-A623-A60F91118B17Q28205698-333FA072-C3AD-44EC-A851-49526CD75DD5Q28596027-7713B302-10D4-4FCC-B78C-28010F4F7BAAQ29547740-9C80F4E4-A523-4141-8F53-EBF7F347CC06Q30450204-39E65EE3-A603-43A8-B3E6-F354CA941231Q30870479-796F992D-FA2B-4C92-8162-AE405B315936Q31649828-22A28235-1BFE-4C2E-ADC1-C907AB5F560CQ33761690-A47E4654-CBBF-449E-94FD-CDA6668708B2Q33958672-95BD9A8B-A71A-4AC3-BC2A-CF23D1D4A3F9Q34585458-3A36CFB8-BFC6-4DC1-84BF-97DDFC6EA7D3Q35077234-C7FC919B-8C8B-491E-9163-85B1062410C7Q35790584-4FD939AD-84BA-4F69-BC2D-7AC8B3DD0113Q35945697-506D9FCF-8C7A-499A-97E8-2755A22EE82DQ36089876-2678A748-05C0-4BD8-9AED-2EBB933F72DCQ36213543-8E5FF4A7-E530-4773-8175-4D9F57BE0D09Q36324671-8A31B79D-3F79-42FF-96E0-858156D51650Q38213708-9EBA6C00-2812-4C15-8396-0F785EF6649FQ38510135-D77E7245-9375-4A76-9D46-98EE295613A8Q39460559-8F13284E-C379-414C-8145-0A523E7E8001Q39584837-F6C021FD-04D7-41B5-BE30-EC85C4D85779Q40442457-FD63B339-827E-44CF-90CB-CB9DCBC0AD4FQ41331822-9493BAA9-26CE-4535-AC0C-6536ED4FED21Q41858762-DABE5D9F-B650-4E38-917B-C805F63DF9B1Q42629955-59DFFCCE-394D-4408-BAD4-213E6E0A1C34Q44881148-B0F498DA-ED6B-46FE-8BDD-A03EBFB38E77Q45318312-9BF15C28-64C5-41F1-B2CC-7C513FE53443Q48350071-4F0ECEAC-BB5B-498B-B506-59989E13A1BC
P2860
Mutational analysis of the regulatory mechanism of PKN: the regulatory region of PKN contains an arachidonic acid-sensitive autoinhibitory domain
description
1999 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1999
@ast
im September 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/09/01)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/09/01)
@nl
наукова стаття, опублікована у вересні 1999
@uk
مقالة علمية (نشرت في سبتمبر 1999)
@ar
name
Mutational analysis of the reg ...... ensitive autoinhibitory domain
@ast
Mutational analysis of the reg ...... ensitive autoinhibitory domain
@en
Mutational analysis of the reg ...... ensitive autoinhibitory domain
@nl
type
label
Mutational analysis of the reg ...... ensitive autoinhibitory domain
@ast
Mutational analysis of the reg ...... ensitive autoinhibitory domain
@en
Mutational analysis of the reg ...... ensitive autoinhibitory domain
@nl
prefLabel
Mutational analysis of the reg ...... ensitive autoinhibitory domain
@ast
Mutational analysis of the reg ...... ensitive autoinhibitory domain
@en
Mutational analysis of the reg ...... ensitive autoinhibitory domain
@nl
P2093
P3181
P1476
Mutational analysis of the reg ...... ensitive autoinhibitory domain
@en
P2093
C. Yoshinaga
M. Miyamoto
M. Toshimori
P304
P3181
P356
10.1093/OXFORDJOURNALS.JBCHEM.A022476
P577
1999-09-01T00:00:00Z