Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene
about
Analysis of folylpoly-gamma-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cellsRetrovirally mediated complementation of the glyB phenotype. Cloning of a human gene encoding the carrier for entry of folates into mitochondriaThe human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoterExpression patterns of the multiple transcripts from the folylpolyglutamate synthetase gene in human leukemias and normal differentiated tissuesAdditional organizational features of the murine folylpolyglutamate synthetase gene. Two remotely situated exons encoding an alternate 5' end and proximal open reading frame under the control of a second promoterConcentration-dependent processivity of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase.Molecular and cellular correlates of methotrexate response in childhood acute lymphoblastic leukemia.Human cytosolic and mitochondrial folylpolyglutamate synthetase are electrophoretically distinct. Expression in antifolate-sensitive and -resistant human cell lines.Classification of ex vivo methotrexate resistance in acute lymphoblastic and myeloid leukaemia.Transcription of the human folylpoly-gamma-glutamate synthetase gene.Synthesis of (6R)- and (6S)-5,10-dideazatetrahydrofolate oligo-gamma-glutamates: kinetics of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetaseExpression of Folate Pathway Genes in Stage III Colorectal Cancer Correlates with Recurrence Status Following Adjuvant Bolus 5-FU-Based Chemotherapy.Organization and alternate splicing of the murine folylpolyglutamate synthetase gene. Different splice variants in L1210 cells encode mitochondrial or cytosolic forms of the enzyme.Mechanisms of antifolate resistance and methotrexate efficacy in leukemia cells.Folate and vitamin B12 metabolism: overview and interaction with riboflavin, vitamin B6, and polymorphisms.Inhibition of human folylpolyglutamate synthetase by diastereomeric phosphinic acid mimics of the tetrahedral intermediate.The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain.Humanizing mouse folate metabolism: conversion of the dual-promoter mouse folylpolyglutamate synthetase gene to the human single-promoter structure.Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy.Methenyltetrahydrofolate synthetase is a high-affinity catecholamine-binding protein.Mammalian fibroblasts lacking mitochondrial NAD+-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase are glycine auxotrophs.The human reduced folate carrier gene is regulated by the AP2 and sp1 transcription factor families and a functional 61-base pair polymorphism.Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition.Posttranscriptionally mediated decreases in folylpolyglutamate synthetase gene expression in some folate analogue-resistant variants of the L1210 cell. Evidence for an altered cognate mRNA in the variants affecting the rate of de novo synthesis of tγ-Glutamyl hydrolase modulation significantly influences global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells.Characterization and Interrelations of One-Carbon Metabolites in Tissues, Erythrocytes, and Plasma in Mice with Dietary Induced Folate Deficiency.Cellular folates prevent polyglutamation of 5, 10-dideazatetrahydrofolate. A novel mechanism of resistance to folate antimetabolites.Molecular cloning, characterization, and regulation of the human mitochondrial serine hydroxymethyltransferase gene.Extracellular folate import across the plasma membraneCytosolic folate export across the plasma membraneConversion of cytosolic THF to THF-polyglutamateConversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamateCytosolic tetrahydrofolate import across the inner mitochondrial membraneMitochondrial tetrahydrofolate export across the inner mitochondrial membraneConversion of mitochondrial THF to THF-polyglutamateComprehensive quantitative measurement of folate polyglutamates in human erythrocytes by ion pairing ultra-performance liquid chromatography/tandem mass spectrometry.
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P2860
Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene
description
1996 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1996
@ast
im Mai 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/05/31)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/05/31)
@nl
наукова стаття, опублікована в травні 1996
@uk
name
Purification and properties of ...... ferential splicing of its gene
@ast
Purification and properties of ...... ferential splicing of its gene
@en
Purification and properties of ...... ferential splicing of its gene
@nl
type
label
Purification and properties of ...... ferential splicing of its gene
@ast
Purification and properties of ...... ferential splicing of its gene
@en
Purification and properties of ...... ferential splicing of its gene
@nl
prefLabel
Purification and properties of ...... ferential splicing of its gene
@ast
Purification and properties of ...... ferential splicing of its gene
@en
Purification and properties of ...... ferential splicing of its gene
@nl
P2093
P2860
P356
P1476
Purification and properties of ...... ferential splicing of its gene
@en
P2093
P2860
P304
13077–13087
P356
10.1074/JBC.271.22.13077
P407
P577
1996-05-31T00:00:00Z