Tyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcription
about
Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytesControlling NF-kappaB activation in T cells by costimulatory receptorsDeficiency of small GTPase Rac2 affects T cell activationThe PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity.Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76.A logical model provides insights into T cell receptor signaling.Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activityCombinatorial signals from CD28 differentially regulate human immunodeficiency virus transcription in T cellsAn enigmatic tail of CD28 signaling.The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism.Beyond the RING: CBL proteins as multivalent adapters.Effect of redox balance alterations on cellular localization of LAT and downstream T-cell receptor signaling pathwaysCD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76?Molecular modifiers of T cell antigen receptor triggering threshold: the mechanism of CD28 costimulatory receptor.Vav1 Regulates T-Cell Activation through a Feedback Mechanism and Crosstalk between the T-Cell Receptor and CD28.Nuclear factor of activated T cells c is a target of p38 mitogen-activated protein kinase in T cellsSelective activation of the c-Jun NH2-terminal protein kinase signaling pathway by stimulatory KIR in the absence of KARAP/DAP12 in CD4+ T cells.Genetic disruption of p38alpha Tyr323 phosphorylation prevents T-cell receptor-mediated p38alpha activation and impairs interferon-gamma production.Protein kinase C theta cooperates with Vav1 to induce JNK activity in T-cells.Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line.Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.TcR and TcR-CD28 engagement of protein kinase B (PKB/AKT) and glycogen synthase kinase-3 (GSK-3) operates independently of guanine nucleotide exchange factor VAV-1.Inhibition of the antigen-induced activation of rodent mast cells by putative Janus kinase 3 inhibitors WHI-P131 and WHI-P154 in a Janus kinase 3-independent manner.DroVav, the Drosophila melanogaster homologue of the mammalian Vav proteins, serves as a signal transducer protein in the Rac and DER pathways.Regulation of T cell activation and anergy by the intensity of the Ca²+ signal in cooperation with other signals.Vav1 couples T cell receptor to serum response factor-dependent transcription via a MEK-dependent pathway.Distinct functions of Vav1 in JNK1 activation in Jurkat T cells versus non-haematopoietic cells.Vav is required for cyclin D2 induction and proliferation of mouse B lymphocytes activated via the antigen Receptor.CD28 dependent Vav1 pathwayTAK1-mediated transcriptional activation of CD28-responsive element and AP-1-binding site within the IL-2 promoter in Jurkat T cells.The role of ERK5 in T-cell signalling.Translocation of Vav1 to CD28Activation of Vav1Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1.The Drosophila proteins Pelle and Tube induce JNK/AP-1 activity in mammalian cells.Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in TH 1 responses
P2860
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P2860
Tyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcription
description
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2000
@ast
im Juni 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/06/16)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/06/16)
@nl
наукова стаття, опублікована в червні 2000
@uk
name
Tyrosine-phosphorylated Vav1 a ...... nd interleukin-2 transcription
@ast
Tyrosine-phosphorylated Vav1 a ...... nd interleukin-2 transcription
@en
Tyrosine-phosphorylated Vav1 a ...... nd interleukin-2 transcription
@nl
type
label
Tyrosine-phosphorylated Vav1 a ...... nd interleukin-2 transcription
@ast
Tyrosine-phosphorylated Vav1 a ...... nd interleukin-2 transcription
@en
Tyrosine-phosphorylated Vav1 a ...... nd interleukin-2 transcription
@nl
prefLabel
Tyrosine-phosphorylated Vav1 a ...... nd interleukin-2 transcription
@ast
Tyrosine-phosphorylated Vav1 a ...... nd interleukin-2 transcription
@en
Tyrosine-phosphorylated Vav1 a ...... nd interleukin-2 transcription
@nl
P2093
P2860
P356
P1476
Tyrosine-phosphorylated Vav1 a ...... nd interleukin-2 transcription
@en
P2093
M. L. Schmitz
S. P. Hehner
T. G. Hofmann
P2860
P304
18160–18171
P356
10.1074/JBC.275.24.18160
P407
P577
2000-06-16T00:00:00Z