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Functional properties of membrane cofactor protein of complement

Functional properties of membrane cofactor protein of complement

http://www.wikidata.org/entity/Q28610962

about

Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome T-cell regulation by CD46 and its relevance in multiple sclerosis Complement and its role in protection and pathogenesis of flavivirus infections Membrane cofactor protein (MCP; CD46) expression in transgenic mice The embryotrophic activity of oviductal cell-derived complement C3b and iC3b, a novel function of complement protein in reproduction.Molecular cloning of membrane cofactor protein (MCP; CD46) on B95a cell, an Epstein-Barr virus-transformed marmoset B cell line: B95a-MCP is susceptible to infection by the CAM, but not the Nagahata strain of the measles virus.Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome.Modeling how CD46 deficiency predisposes to atypical hemolytic uremic syndrome Inhibiting complement activation on cells at the step of C3 cleavage.Targeted and restricted complement activation on acrosome-reacted spermatozoa.Morbillivirus downregulation of CD46.Expression of human CD46 modulates inflammation associated with GalTKO lung xenograft injury Decay accelerating factor (CD55)-mediated attenuation of complement: therapeutic implications for age-related macular degeneration.Dense deposit disease.The complement system in human reproduction.Expression of the complement regulatory proteins decay accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and CD59 in the normal human uterine cervix and in premalignant and malignant cervical disease Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids Role of virion-associated glycosylphosphatidylinositol-linked proteins CD55 and CD59 in complement resistance of cell line-derived and primary isolates of HIV-1 Nitrite Modification of Extracellular Matrix Alters CD46 Expression and VEGF Release in Human Retinal Pigment Epithelium.Expression of membrane cofactor protein (MCP, CD46) in human liver diseases.Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells.Initiation and regulation of complement during hemolytic transfusion reactions.Diversity of sites for measles virus binding and for inactivation of complement C3b and C4b on membrane cofactor protein CD46.Hepatitis C virus infection upregulates CD55 expression on the hepatocyte surface and promotes association with virus particles.Octamerization enables soluble CD46 receptor to neutralize measles virus in vitro and in vivo.Distinct CD55 Isoform Synthesis and Inhibition of Complement-Dependent Cytolysis by Hepatitis C Virus.Adenovirus type 11 uses CD46 as a cellular receptor.Downregulation of human CD46 by adenovirus serotype 35 vectors.Human regulator of complement activation (RCA) gene family proteins and their relationship to microbial infection.Membrane proteins that protect against complement lysis.Therapeutic uses of recombinant complement protein inhibitors.Evidence for distinct complement regulatory and measles virus binding sites on CD46 SCR2.Oligodendrocytes lack glycolipid anchored proteins which protect them against complement lysis. Restoration of resistance to lysis by incorporation of CD59.Altered expression of host-encoded complement regulators on human cytomegalovirus-infected cells.Characterization of a glycosyl-phosphatidylinositol anchor-deficient subline of Raji cells. An analysis of the functional importance of complement inhibitors on the Raji cell line.Homologous C3 deposition and homotypic cell adhesion in a human myeloid cell line, P39.Polymorphism and proteolytic fragments of granulocyte membrane cofactor protein (MCP, CD46) of complement.Characterization of three monoclonal antibodies to membrane co-factor protein (MCP) of the complement system and quantification of MCP by radioassay.Complement-mediated tumor cell damage induced by antibodies against membrane cofactor protein (MCP, CD46).

P2860

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P2860

Functional properties of membrane cofactor protein of complement

http://www.wikidata.org/entity/Q28610962

description

1989 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1989 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 1989

@ast

im Dezember 1989 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 1989/12/01)

@sk

vědecký článek publikovaný v roce 1989

@cs

wetenschappelijk artikel (gepubliceerd op 1989/12/01)

@nl

наукова стаття, опублікована в грудні 1989

@uk

مقالة علمية (نشرت في ديسمبر 1989)

@ar

name

Functional properties of membrane cofactor protein of complement

@ast

Functional properties of membrane cofactor protein of complement

@en

Functional properties of membrane cofactor protein of complement

@nl

type

label

Functional properties of membrane cofactor protein of complement

@ast

Functional properties of membrane cofactor protein of complement

@en

Functional properties of membrane cofactor protein of complement

@nl

prefLabel

Functional properties of membrane cofactor protein of complement

@ast

Functional properties of membrane cofactor protein of complement

@en

Functional properties of membrane cofactor protein of complement

@nl

P1433

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P1476

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P2093

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P2860

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P3181

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P356

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P407

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P577

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P5875

Q28610962-4A5F1544-185E-4E19-A4B0-860597BC731D

P698

Q28610962-4EE06E72-DE2A-4CC3-81D6-9F4D38AE2BD5

P932

Q28610962-6144EBD9-607D-448A-9A0E-45E027CE612A

P3181

P356

P1433

Biochemical Journal

P1476

Functional properties of membrane cofactor protein of complement

@en

P2093

J. P. Atkinson

http://www.w3.org/2001/XMLSchema#string

T. Seya

http://www.w3.org/2001/XMLSchema#string

P2860

Isolation of a human erythrocyte membrane glycoprotein with decay-accelerating activity for C3 convertases of the complement system

Complement receptor is an inhibitor of the complement cascade

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

Interaction between the third complement protein and cell surface macromolecules

Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane

Generation of three different fragments of bound C3 with purified factor I or serum. I. Requirements for factor H vs CR1 cofactor activity

Inhibition of complement activation on the surface of cells after incorporation of decay-accelerating factor (DAF) into their membranes

Cleavage of C2 by C1s into the antigenically distinct fragments C2a and C2b: demonstration of binding of C2b to C4b

Cleavage of C4b by C3b inactivator: production of a nicked form of C4b, C4b', as an intermediate cleavage product of C4b by C3b inactivator

Activation of the alternative complement pathway due to resistance of zymosan-bound amplification convertase to endogenous regulatory mechanisms.

P304

581–588

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

4328404

http://www.w3.org/2001/XMLSchema#string

P356

10.1042/BJ2640581

http://www.w3.org/2001/XMLSchema#string

P407

P433

2

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P478

264

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P577

1989-12-01T00:00:00Z

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P5875

20675586

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P698

2481448

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P932

1133618

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