Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation
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The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loopEnabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitorHierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activationHeteromerization of the c Chain with the Interleukin-9 Receptor Subunit Leads to STAT Activation and Prevention of ApoptosisA dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling.Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains.Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency.Janus kinases: components of multiple signaling pathways.Jak2-Stat5 interactions analyzed in yeast.Regulation of the Jak2 tyrosine kinase by its pseudokinase domainThe pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction.Jak/STAT pathways in cytokine signaling and myeloproliferative disorders: approaches for targeted therapies.CXCR4 utilization is sufficient to trigger CD4+ T cell depletion in HIV-1-infected human lymphoid tissue.The interleukin (IL)-2 family cytokines: survival and proliferation signaling pathways in T lymphocytes.Differential regulation of Janus kinase 3 (JAK3) in bovine preovulatory follicles and identification of JAK3 interacting proteins in granulosa cellsRegulation of inflammation by interleukin-4: a review of "alternatives"Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).Depletion of cellular glutathione modulates LIF-induced JAK1-STAT3 signaling in cardiac myocytes.Oligomerization and scaffolding functions of the erythropoietin receptor cytoplasmic tail.Anticancer agent xanthohumol inhibits IL-2 induced signaling pathways involved in T cell proliferation.Combinatorial Signal Transduction Responses Mediated by Interleukin-2 and -4 Receptors in a Helper TH2 Cell Line.Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol.IL-2 enhances cervical cancer cells proliferation and JAK3/STAT5 phosphorylation at low doses, while at high doses IL-2 has opposite effects.Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain.Anti-apoptotic signaling by the interleukin-2 receptor reveals a function for cytoplasmic tyrosine residues within the common gamma (gamma c) receptor subunit.Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation.Janus kinase 3: a novel target for selective transplant immunosupression.JAK activation
P2860
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P2860
Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation
description
1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1997
@ast
im November 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/11/01)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/11/01)
@nl
наукова стаття, опублікована в листопаді 1997
@uk
مقالة علمية (نشرت في نوفمبر 1997)
@ar
name
Janus kinases in interleukin-2 ...... ed by tyrosine phosphorylation
@ast
Janus kinases in interleukin-2 ...... ed by tyrosine phosphorylation
@en
Janus kinases in interleukin-2 ...... ed by tyrosine phosphorylation
@nl
type
label
Janus kinases in interleukin-2 ...... ed by tyrosine phosphorylation
@ast
Janus kinases in interleukin-2 ...... ed by tyrosine phosphorylation
@en
Janus kinases in interleukin-2 ...... ed by tyrosine phosphorylation
@nl
prefLabel
Janus kinases in interleukin-2 ...... ed by tyrosine phosphorylation
@ast
Janus kinases in interleukin-2 ...... ed by tyrosine phosphorylation
@en
Janus kinases in interleukin-2 ...... ed by tyrosine phosphorylation
@nl
P2093
P3181
P1433
P1476
Janus kinases in interleukin-2 ...... ed by tyrosine phosphorylation
@en
P2093
M. A. Goldsmith
S. L. Gaffen
W. C. Greene
P304
P3181
P356
10.1016/S0960-9822(06)00369-1
P407
P577
1997-11-01T00:00:00Z