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Network-based drug discovery by integrating systems biology and computational technologies

Network-based drug discovery by integrating systems biology and computational technologies

http://www.wikidata.org/entity/Q28677268

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Animal-Free Chemical Safety Assessment Synergistic Effects of Chinese Herbal Medicine: A Comprehensive Review of Methodology and Current Research Computational approaches in target identification and drug discovery Network-based approaches in drug discovery and early development Combination therapeutics in complex diseases Visualization of network target crosstalk optimizes drug synergism in myocardial ischemia Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action PhIN: A Protein Pharmacology Interaction Network Database Enhancing systems medicine beyond genotype data by dynamic patient signatures: having information and using it too A Systems Biology-Based Investigation into the Pharmacological Mechanisms of Sheng-ma-bie-jia-tang Acting on Systemic Lupus Erythematosus by Multi-Level Data Integration Identifying the gene signatures from gene-pathway bipartite network guarantees the robust model performance on predicting the cancer prognosis.21st century natural product research and drug development and traditional medicines DCDB 2.0: a major update of the drug combination database.Detection for pathway effect contributing to disease in systems epidemiology with a case-control design.Biased random walk model for the prioritization of drug resistance associated proteins.Systematic synergy modeling: understanding drug synergy from a systems biology perspective.Novel multifunctional pharmacology of lobinaline, the major alkaloid from Lobelia cardinalis.Taxifolin synergizes Andrographolide-induced cell death by attenuation of autophagy and augmentation of caspase dependent and independent cell death in HeLa cells.An integrated network platform for contextual prioritization of drugs and pathways The Predicted Proteomic Network Associated with the Antiarthritic Action of Qingfu Guanjieshu in Collagen-II-Induced Arthritis in Rats Exploring the ligand-protein networks in traditional chinese medicine: current databases, methods, and applications A validated cellular biobank for β-thalassemia.A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula: A Trial on Shu-feng-jie-du Formula.Network pharmacology strategies toward multi-target anticancer therapies: from computational models to experimental design principles.Rh2E2, a novel metabolic suppressor, specifically inhibits energy-based metabolism of tumor cells.Artemisinin rewires the protein interaction network in cancer cells: network analysis, pathway identification, and target prediction.DEsubs: an R package for flexible identification of differentially expressed subpathways using RNA-seq experiments.Herb Network Analysis for a Famous TCM Doctor's Prescriptions on Treatment of Rheumatoid Arthritis Novel harmonic regularization approach for variable selection in Cox's proportional hazards model.Docking studies and network analyses reveal capacity of compounds from Kandelia rheedii to strengthen cellular immunity by interacting with host proteins during tuberculosis infection.Systems pharmacology strategies for anticancer drug discovery based on natural products.Network Pharmacology Strategies Toward Multi-Target Anticancer Therapies: From Computational Models to Experimental Design Principles.PerSubs: A Graph-Based Algorithm for the Identification of Perturbed Subpathways Caused by Complex Diseases.Systems biology: mathematical modeling and model analysis.Thymic function in the regulation of T cells, and molecular mechanisms underlying the modulation of cytokines and stress signaling (Review).Fuzzy optimization for detecting enzyme targets of human uric acid metabolism.Sulfonanilide Derivatives in Identifying Novel Aromatase Inhibitors by Applying Docking, Virtual Screening, and MD Simulations Studies.A systems pharmacology-oriented discovery of a new therapeutic use of the TCM formula Liuweiwuling for liver failure.A systematic study of chemogenomics of carbohydrates.Integration of Metabonomics and Transcriptomics Reveals the Therapeutic Effects and Mechanisms of Baoyuan Decoction for Myocardial Ischemia.

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Network-based drug discovery by integrating systems biology and computational technologies

http://www.wikidata.org/entity/Q28677268

description

2013 nî lūn-bûn

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2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2013 թվականի հուլիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Network-based drug discovery b ...... and computational technologies

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Network-based drug discovery b ...... and computational technologies

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Network-based drug discovery b ...... and computational technologies

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Network-based drug discovery b ...... and computational technologies

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Network-based drug discovery b ...... and computational technologies

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Network-based drug discovery b ...... and computational technologies

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Network-based drug discovery b ...... and computational technologies

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Network-based drug discovery b ...... and computational technologies

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Network-based drug discovery b ...... and computational technologies

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Briefings in Bioinformatics

P1476

Network-based drug discovery b ...... and computational technologies

@en

P2093

Elaine L Leung

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Hua Zhou

http://www.w3.org/2001/XMLSchema#string

Liang Liu

http://www.w3.org/2001/XMLSchema#string

Zhi-Hong Jiang

http://www.w3.org/2001/XMLSchema#string

Zhi-Wei Cao

http://www.w3.org/2001/XMLSchema#string

P2860

Artemisinin: discovery from the Chinese herbal garden

Genomic analysis identifies association of Fusobacterium with colorectal carcinoma

The NIH Human Microbiome Project

Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma

A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia

A network-based multi-target computational estimation scheme for anticoagulant activities of compounds

Discovery of molecular mechanisms of traditional Chinese medicinal formula Si-Wu-Tang using gene expression microarray and connectivity map

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491-505

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1791192

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10.1093/BIB/BBS043

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4

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14

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230644421

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22877768

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information system

computational biology

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3713711

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