On the origins of Mendelian disease genes in man: the impact of gene duplication
about
Defining the role of essential genes in human diseaseIdentification of 526 conserved metazoan genetic innovations exposes a new role for cofactor E-like in neuronal microtubule homeostasisSpider Transcriptomes Identify Ancient Large-Scale Gene Duplication Event Potentially Important in Silk Gland EvolutionEvolutionary profiling reveals the heterogeneous origins of classes of human disease genes: implications for modeling disease genetics in animalsIntegrating Diverse Types of Genomic Data to Identify Genes that Underlie Adverse Pregnancy PhenotypesStudying tumorigenesis through network evolution and somatic mutational perturbations in the cancer interactomeHuman monogenic disease genes have frequently functionally redundant paralogs.Genome-wide analysis of human hotspot intersected genes highlights the roles of meiotic recombination in evolution and diseaseFruit flies in biomedical research.Human dominant disease genes are enriched in paralogs originating from whole genome duplication.Identification of Ohnolog Genes Originating from Whole Genome Duplication in Early Vertebrates, Based on Synteny Comparison across Multiple Genomes.Global analysis of human duplicated genes reveals the relative importance of whole-genome duplicates originated in the early vertebrate evolution.Using Disease-Associated Coding Sequence Variation to Investigate Functional Compensation by Human Paralogous Proteins.Establishing the precise evolutionary history of a gene improves prediction of disease-causing missense mutations.Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates.ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome.Locus heterogeneity disease genes encode proteins with high interconnectivity in the human protein interaction network.Selective Constraints on Coding Sequences of Nervous System Genes Are a Major Determinant of Duplicate Gene Retention in Vertebrates.Pooled genome-wide CRISPR screening for basal and context-specific fitness gene essentiality in cells
P2860
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P2860
On the origins of Mendelian disease genes in man: the impact of gene duplication
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2012 nî lūn-bûn
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2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
On the origins of Mendelian disease genes in man: the impact of gene duplication
@ast
On the origins of Mendelian disease genes in man: the impact of gene duplication
@en
On the origins of Mendelian disease genes in man: the impact of gene duplication
@nl
type
label
On the origins of Mendelian disease genes in man: the impact of gene duplication
@ast
On the origins of Mendelian disease genes in man: the impact of gene duplication
@en
On the origins of Mendelian disease genes in man: the impact of gene duplication
@nl
prefLabel
On the origins of Mendelian disease genes in man: the impact of gene duplication
@ast
On the origins of Mendelian disease genes in man: the impact of gene duplication
@en
On the origins of Mendelian disease genes in man: the impact of gene duplication
@nl
P2860
P356
P1476
On the origins of Mendelian disease genes in man: the impact of gene duplication
@en
P2093
David L Robertson
Jonathan E Dickerson
P2860
P356
10.1093/MOLBEV/MSR111
P407
P577
2012-01-01T00:00:00Z