B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity - Wikidata - wikimedia - TriplyDB

B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity

B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity

http://www.wikidata.org/entity/Q28680673

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The role of T cell receptor signaling thresholds in guiding T cell fate decisions B lymphocyte antigen receptor signaling: initiation, amplification, and regulation Regulatory constraints in the generation and differentiation of IgE-expressing B cells CD73 expression is dynamically regulated in the germinal center and bone marrow plasma cells are diminished in its absence Signaling by the phosphoinositide 3-kinase family in immune cells Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge Germinal center B cells recognize antigen through a specialized immune synapse architecture.Integrin-mediated interactions between B cells and follicular dendritic cells influence germinal center B cell fitness Shp1 signalling is required to establish the long-lived bone marrow plasma cell pool.PDK1 regulates B cell differentiation and homeostasis.Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells.Germinal center B cell maintenance and differentiation are controlled by distinct NF-κB transcription factor subunits.Identification of a functional nuclear translocation sequence in hPPIP5K2.Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen Dynamics of B cells in germinal centres.IL-4 upregulates Igα and Igβ protein, resulting in augmented IgM maturation and B cell receptor-triggered B cell activation.Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus.Growth Conditions and Cell Cycle Phase Modulate Phase Transition Temperatures in RBL-2H3 Derived Plasma Membrane Vesicles.The RNA-binding protein HuR is essential for the B cell antibody response.Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B Cells CRISPR-Mediated Slamf1Δ/Δ Slamf5Δ/Δ Slamf6Δ/Δ Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects DC-SIGN-expressing macrophages trigger activation of mannosylated IgM B-cell receptor in follicular lymphoma.Reactivation of IgG-switched memory B cells by BCR-intrinsic signal amplification promotes IgG antibody production.Imbalanced PTEN and PI3K Signaling Impairs Class Switch Recombination.CD22 is required for formation of memory B cell precursors within germinal centers.Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity.A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells.SHP-1 phosphatase activity counteracts increased T cell receptor affinity.B cell and/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells.Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development.CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling.Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells.The Bruton tyrosine kinase (BTK) inhibitor PCI-32765 synergistically increases proteasome inhibitor activity in diffuse large-B cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) cells sensitive or resistant to bortezomib.YY1 plays an essential role at all stages of B-cell differentiation.A role for gut-associated lymphoid tissue in shaping the human B cell repertoire The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response.mTOR has distinct functions in generating versus sustaining humoral immunity.IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity.

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P2860

B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity

http://www.wikidata.org/entity/Q28680673

description

2012 nî lūn-bûn

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2012 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հունիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

B cell receptor signal transdu ...... d by high phosphatase activity

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B cell receptor signal transdu ...... d by high phosphatase activity

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B cell receptor signal transdu ...... d by high phosphatase activity

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type

label

B cell receptor signal transdu ...... d by high phosphatase activity

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B cell receptor signal transdu ...... d by high phosphatase activity

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B cell receptor signal transdu ...... d by high phosphatase activity

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prefLabel

B cell receptor signal transdu ...... d by high phosphatase activity

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B cell receptor signal transdu ...... d by high phosphatase activity

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B cell receptor signal transdu ...... d by high phosphatase activity

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B cell receptor signal transdu ...... d by high phosphatase activity

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Ashraf M Khalil

http://www.w3.org/2001/XMLSchema#string

John C Cambier

http://www.w3.org/2001/XMLSchema#string

Mark J Shlomchik

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P2860

Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection

Germinal centers

TCR-induced transmembrane signaling by peptide/MHC class II via associated Ig-alpha/beta dimers.

B cell antigen receptor signaling and internalization are mutually exclusive events.

Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: regulators of B cell signal transduction.

Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling.

Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease

B cell antigen receptor signaling 101.

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1178-81

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