Good codons, bad transcript: large reductions in gene expression and fitness arising from synonymous mutations in a key enzyme - Wikidata - wikimedia - TriplyDB

Good codons, bad transcript: large reductions in gene expression and fitness arising from synonymous mutations in a key enzyme

Good codons, bad transcript: large reductions in gene expression and fitness arising from synonymous mutations in a key enzyme

http://www.wikidata.org/entity/Q28709242

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Strong purifying selection at synonymous sites in D. melanogaster The role of mRNA structure in bacterial translational regulation Decoding mechanisms by which silent codon changes influence protein biogenesis and function Evaluating the fitness cost of protein expression in Saccharomyces cerevisiae.Roles of solvent accessibility and gene expression in modeling protein sequence evolution Protein functional features are reflected in the patterns of mRNA translation speed.The evolution of bacterial DNA base composition.Plasmid and clonal interference during post horizontal gene transfer evolution.Selection on synonymous codons in mammalian rhodopsins: a possible role in optimizing translational processes A critical analysis of codon optimization in human therapeutics.Synonymous codon bias and functional constraint on GC3-related DNA backbone dynamics in the prokaryotic nucleoid.SENCA: A Multilayered Codon Model to Study the Origins and Dynamics of Codon Usage.Effective population size does not predict codon usage bias in mammals Methylamine utilization via the N-methylglutamate pathway in Methylobacterium extorquens PA1 involves a novel flow of carbon through C1 assimilation and dissimilation pathways.A nutrient-driven tRNA modification alters translational fidelity and genome-wide protein coding across an animal genus A novel pair of inducible expression vectors for use in Methylobacterium extorquens.Laboratory divergence of Methylobacterium extorquens AM1 through unintended domestication and past selection for antibiotic resistance A condition-specific codon optimization approach for improved heterologous gene expression in Saccharomyces cerevisiae.The relationship between dN/dS and scaled selection coefficients.Genetic and phenotypic comparison of facultative methylotrophy between Methylobacterium extorquens strains PA1 and AM1.The Selective Advantage of Synonymous Codon Usage Bias in Salmonella.Revelation of Influencing Factors in Overall Codon Usage Bias of Equine Influenza Viruses Experimental Evolution of Escherichia coli Harboring an Ancient Translation Protein Synonymous Genetic Variation in Natural Isolates of Escherichia coli Does Not Predict Where Synonymous Substitutions Occur in a Long-Term Experiment Large-Effect Beneficial Synonymous Mutations Mediate Rapid and Parallel Adaptation in a Bacterium.Stabilizing selection, purifying selection, and mutational bias in finite populations.Experimental Horizontal Gene Transfer of Methylamine Dehydrogenase Mimics Prevalent Exchange in Nature and Overcomes the Methylamine Growth Constraints Posed by the Sub-Optimal N-Methylglutamate Pathway Mutational pressure dictates synonymous codon usage in freshwater unicellular α - cyanobacterial descendant Paulinella chromatophora and β - cyanobacterium Synechococcus elongatus PCC6301.Depletion of Shine-Dalgarno Sequences within Bacterial Coding Regions Is Expression Dependent.Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis.Deciphering the rules by which dynamics of mRNA secondary structure affect translation efficiency in Saccharomyces cerevisiae.Codon bias and gene ontology in holometabolous and hemimetabolous insects.The Need for Integrated Approaches in Metabolic Engineering.The ribosome in action: Tuning of translational efficiency and protein folding.Pathway Design, Engineering, and Optimization.Genetic and codon usage bias analyses of polymerase genes of equine influenza virus and its relation to evolution.Love the one you're with: replicate viral adaptations converge on the same phenotypic change.Coevolution mechanisms that adapt viruses to genetic code variations implemented in their hosts.Genetic Code Optimization for Cotranslational Protein Folding: Codon Directional Asymmetry Correlates with Antiparallel Betasheets, tRNA Synthetase Classes Codon usage is less optimized in eukaryotic gene segments encoding intrinsically disordered regions than in those encoding structural domains.

P2860

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P2860

Good codons, bad transcript: large reductions in gene expression and fitness arising from synonymous mutations in a key enzyme

http://www.wikidata.org/entity/Q28709242

description

2013 nî lūn-bûn

@nan

2013 թուականի Մարտին հրատարակուած գիտական յօդուած

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2013 թվականի մարտին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Good codons, bad transcript: l ...... mous mutations in a key enzyme

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Good codons, bad transcript: l ...... mous mutations in a key enzyme

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Good codons, bad transcript: l ...... mous mutations in a key enzyme

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type

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Good codons, bad transcript: l ...... mous mutations in a key enzyme

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Good codons, bad transcript: l ...... mous mutations in a key enzyme

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Good codons, bad transcript: l ...... mous mutations in a key enzyme

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Good codons, bad transcript: l ...... mous mutations in a key enzyme

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Good codons, bad transcript: l ...... mous mutations in a key enzyme

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Good codons, bad transcript: l ...... mous mutations in a key enzyme

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Molecular Biology and Evolution

P1476

Good codons, bad transcript: l ...... mous mutations in a key enzyme

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P2093

Christopher J Marx

http://www.w3.org/2001/XMLSchema#string

N Cecilia Martinez-Gomez

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P2860

Design parameters to control synthetic gene expression in Escherichia coli

Selection on Codon Bias

In vivo introduction of unpreferred synonymous codons into the Drosophila Adh gene results in reduced levels of ADH protein

Virus attenuation by genome-scale changes in codon pair bias

Variation in the strength of selected codon usage bias among bacteria

Association between translation efficiency and horizontal gene transfer within microbial communities

Codon usage and tRNA content in unicellular and multicellular organisms

A "silent" polymorphism in the MDR1 gene changes substrate specificity

How do synonymous mutations affect fitness?

Balanced codon usage optimizes eukaryotic translational efficiency.

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549-60

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scholarly article

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2056108

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10.1093/MOLBEV/MSS273

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3

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30

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D. Allan Drummond

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2013-03-01T00:00:00Z

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233886292

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23223712

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3563975

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