Low level sequence variant analysis of recombinant proteins: an optimized approach
about
Rapid identification of an antibody DNA construct rearrangement sequence variant by mass spectrometryIdentification and characterization of a -1 reading frameshift in the heavy chain constant region of an IgG1 recombinant monoclonal antibody produced in CHO cellsUtilization of sequence variants as biomarkers to analyze population dynamics in cloned cell lines.Improved sequence variant analysis strategy by automated false positive removal.A hybrid approach identifies metabolic signatures of high-producers for chinese hamster ovary clone selection and process optimization.Identifying low-level sequence variants via next generation sequencing to aid stable CHO cell line screening.Trace element associated reduction of norleucine and norvaline accumulation during oxygen limitation in a recombinant Escherichia coli fermentation.An optimized approach to the rapid assessment and detection of sequence variants in recombinant protein products.Molecular polygamy: The promiscuity of l-phenylalanyl-tRNA-synthetase triggers misincorporation of meta- and ortho-tyrosine in monoclonal antibodies expressed by Chinese hamster ovary cells.Improving the accuracy of recombinant protein production through integration of bioinformatics, statistical and mass spectrometry methodologies.Development of a pre-glycoengineered CHO-K1 host cell line for the expression of antibodies with enhanced Fc mediated effector function.Identification of multiple serine to asparagine sequence variation sites in an intended copy product of LUCENTIS® by mass spectrometry.Deep sequencing reveals different compositions of mRNA transcribed from the F8 gene in a panel of FVIII-producing CHO cell lines.
P2860
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P2860
Low level sequence variant analysis of recombinant proteins: an optimized approach
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Low level sequence variant analysis of recombinant proteins: an optimized approach
@ast
Low level sequence variant analysis of recombinant proteins: an optimized approach
@en
Low level sequence variant analysis of recombinant proteins: an optimized approach
@nl
type
label
Low level sequence variant analysis of recombinant proteins: an optimized approach
@ast
Low level sequence variant analysis of recombinant proteins: an optimized approach
@en
Low level sequence variant analysis of recombinant proteins: an optimized approach
@nl
prefLabel
Low level sequence variant analysis of recombinant proteins: an optimized approach
@ast
Low level sequence variant analysis of recombinant proteins: an optimized approach
@en
Low level sequence variant analysis of recombinant proteins: an optimized approach
@nl
P2093
P2860
P1433
P1476
Low level sequence variant analysis of recombinant proteins: an optimized approach
@en
P2093
Apollon Papadimitriou
Björn Mautz
Frank Wiegeshoff
Ingo H Gorr
Jörg Thomas Regula
Oliver Popp
Ulrich Göpfert
Ulrike E E Vollertsen
P2860
P304
P356
10.1371/JOURNAL.PONE.0040328
P407
P577
2012-01-01T00:00:00Z