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The mammalian PYHIN gene family: phylogeny, evolution and expression

The mammalian PYHIN gene family: phylogeny, evolution and expression

http://www.wikidata.org/entity/Q28727434

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Pyroptotic cell death defends against intracellular pathogens Structure of the Absent in Melanoma 2 (AIM2) Pyrin Domain Provides Insights into the Mechanisms of AIM2 Autoinhibition and Inflammasome Assembly Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses IFI16 Preferentially Binds to DNA with Quadruplex Structure and Enhances DNA Quadruplex Formation Unique Loss of the PYHIN Gene Family in Bats Amongst Mammals: Implications for Inflammasome Sensing A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype.Comparative genomics reveals contraction in olfactory receptor genes in bats The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense.Wanderings in biochemistry.Nuclear DNA sensor IFI16 as circulating protein in autoimmune diseases is a signal of damage that impairs endothelial cells through high-affinity membrane binding.Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives.Regulation of inflammasome activation.Tex19 and Sectm1 concordant molecular phylogenies support co-evolution of both eutherian-specific genes.DNA-sensing inflammasomes: regulation of bacterial host defense and the gut microbiota.A vast genomic deletion in the C56BL/6 genome affects different genes within the Ifi200 cluster on chromosome 1 and mediates obesity and insulin resistance.DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease.AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC.Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways.DNA recognition in immunity and disease.Immune sensing of DNA Microbial DNA recognition by cGAS-STING and other sensors in dendritic cells in inflammatory bowel diseases.The roles of interferon-inducible p200 family members IFI16 and p204 in innate immune responses, cell differentiation and proliferation.AIM2-Like Receptors Positively and Negatively Regulate the Interferon Response Induced by Cytosolic DNA Regulation of inflammasomes by ubiquitination.Nucleic acid recognition orchestrates the anti-viral response to retroviruses.Inflammasomes and its importance in viral infections.What do we know about the inflammasome in humans?Avian Interferons and Their Antiviral Effectors.Mouse pyrin and HIN domain family member 1 (pyhin1) protein positively regulates LPS-induced IFN-β and NO production in macrophages.Mechanisms governing inflammasome activation, assembly and pyroptosis induction.The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA.Correcting the NLRP3 inflammasome deficiency in macrophages from autoimmune NZB mice with exon skipping antisense oligonucleotides.The Extracellular IFI16 Protein Propagates Inflammation in Endothelial Cells Via p38 MAPK and NF-κB p65 Activation.AIM2 inflammasome activation and regulation: A structural perspective.The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.

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P2860

The mammalian PYHIN gene family: phylogeny, evolution and expression

http://www.wikidata.org/entity/Q28727434

description

2012 nî lūn-bûn

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2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2012 թվականի օգոստոսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

The mammalian PYHIN gene family: phylogeny, evolution and expression

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The mammalian PYHIN gene family: phylogeny, evolution and expression

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The mammalian PYHIN gene family: phylogeny, evolution and expression

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The mammalian PYHIN gene family: phylogeny, evolution and expression

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The mammalian PYHIN gene family: phylogeny, evolution and expression

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The mammalian PYHIN gene family: phylogeny, evolution and expression

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The mammalian PYHIN gene family: phylogeny, evolution and expression

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The mammalian PYHIN gene family: phylogeny, evolution and expression

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The mammalian PYHIN gene family: phylogeny, evolution and expression

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1471-2148-12-140

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BMC Evolutionary Biology

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The mammalian PYHIN gene family: phylogeny, evolution and expression

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Eva Z Curley

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Jasmyn A Cridland

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Karin S Kassahn

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Initial sequencing and analysis of the human genome

BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources.

A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway

IFI16 is an innate immune sensor for intracellular DNA

AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model

Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha

IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection

p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation

The inflammasomes

Binding of an interferon-inducible protein (p202) to the retinoblastoma protein

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1471-2148-12-140

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140

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scholarly article

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912287

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10.1186/1471-2148-12-140

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1

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12

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Matthew J. Sweet

Katryn J. Stacey

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2012-08-07T00:00:00Z

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230631616

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