Mitochondria-specific accumulation of amyloid β induces mitochondrial dysfunction leading to apoptotic cell death
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Diverse molecular targets for therapeutic strategies in Alzheimer's diseaseMitochondria-Targeted Protective Compounds in Parkinson's and Alzheimer's DiseasesStem cell treatment for Alzheimer's diseaseMitochondrial dysfunction: different routes to Alzheimer's disease therapyHDAC6 inhibitor blocks amyloid beta-induced impairment of mitochondrial transport in hippocampal neuronsDynamics of Human Mitochondrial Complex I Assembly: Implications for Neurodegenerative DiseasesMitochondrial stress signaling promotes cellular adaptationsCoenzyme Q10 protects human endothelial cells from β-amyloid uptake and oxidative stress-induced injuryMechanisms of U87 astrocytoma cell uptake and trafficking of monomeric versus protofibril Alzheimer's disease amyloid-β proteinsReduced IRE1α mediates apoptotic cell death by disrupting calcium homeostasis via the InsP3 receptor.Plaque-associated lipids in Alzheimer's diseased brain tissue visualized by nonlinear microscopyAcute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation.S14G-humanin restored cellular homeostasis disturbed by amyloid-beta proteinThe neuroprotective effect of Klotho is mediated via regulation of members of the redox system.rAAV/ABAD-DP-6His attenuates oxidative stress-induced injury of PC12 cells.Crucial role of calbindin-D28k in the pathogenesis of Alzheimer's disease mouse model.Beta-amyloid oligomers activate apoptotic BAK pore for cytochrome c release.sCD44 internalization in human trabecular meshwork cells.RNA-seq analysis of broiler liver transcriptome reveals novel responses to high ambient temperature.The Broad Impact of TOM40 on Neurodegenerative Diseases in AgingThe role of mitochondrial DNA mutation on neurodegenerative diseases.CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption and pathogenesis of Alzheimer's disease.Involvement of Intracellular and Mitochondrial Aβ in the Ameliorative Effects of Huperzine A against Oligomeric Aβ42-Induced Injury in Primary Rat Neurons.Increased neuronal PreP activity reduces Aβ accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease's mouse modelMetabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration.Cytosolic Extract of Human Adipose Stem Cells Reverses the Amyloid Beta-Induced Mitochondrial Apoptosis via P53/Foxo3a Pathway.Novel antioxidants protect mitochondria from the effects of oligomeric amyloid beta and contribute to the maintenance of epigenome function.Stress resistance and lifespan are increased in C. elegans but decreased in S. cerevisiae by mafr-1/maf1 deletion.Mitochondrial ATP synthase activity is impaired by suppressed O-GlcNAcylation in Alzheimer's disease.SOD2 in mitochondrial dysfunction and neurodegeneration.Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset.Early onset Alzheimer's disease and oxidative stress.High-dose of vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brain of 5XFAD mice.The Function of the Mitochondrial Calcium Uniporter in Neurodegenerative Disorders.Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation.Mitochondrial FOXO3a is involved in amyloid β peptide-induced mitochondrial dysfunction.Physical Exercise and Brain Mitochondrial Fitness: The Possible Role Against Alzheimer's Disease.Mitochondrial Regulatory Pathways in the Pathogenesis of Alzheimer's Disease.Loss of mitofusin 2 links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells.Intromitochondrial IκB/NF-κB signaling pathway is involved in amyloid β peptide-induced mitochondrial dysfunction.
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Mitochondria-specific accumulation of amyloid β induces mitochondrial dysfunction leading to apoptotic cell death
description
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique PLoS ONE
@fr
artículu científicu espublizáu en 2012
@ast
im Januar 2012 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 2012)
@en
vedecký článok (publikovaný 2012)
@sk
vědecký článek publikovaný v roce 2012
@cs
wetenschappelijk artikel (gepubliceerd in 2012)
@nl
наукова стаття, опублікована у 2012
@uk
name
Mitochondria-specific accumula ...... eading to apoptotic cell death
@ast
Mitochondria-specific accumula ...... eading to apoptotic cell death
@en
Mitochondria-specific accumula ...... eading to apoptotic cell death
@nl
type
label
Mitochondria-specific accumula ...... eading to apoptotic cell death
@ast
Mitochondria-specific accumula ...... eading to apoptotic cell death
@en
Mitochondria-specific accumula ...... eading to apoptotic cell death
@nl
prefLabel
Mitochondria-specific accumula ...... eading to apoptotic cell death
@ast
Mitochondria-specific accumula ...... eading to apoptotic cell death
@en
Mitochondria-specific accumula ...... eading to apoptotic cell death
@nl
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P3181
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P1476
Mitochondria-specific accumula ...... eading to apoptotic cell death
@en
P2093
Hyun-Seok Hong
Inhee Mook-Jung
Jayoung Byun
Moon-Yong Cha
Sun-Ho Han
Sung Min Son
Young-Ju Choi
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P304
P3181
P356
10.1371/JOURNAL.PONE.0034929
P407
P577
2012-01-01T00:00:00Z