Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-β1
about
Perforin and granzyme B have separate and distinct roles during atherosclerotic plaque development in apolipoprotein E knockout miceProteoglycan form and function: A comprehensive nomenclature of proteoglycansSerpina3n accelerates tissue repair in a diabetic mouse model of delayed wound healingGranzyme B degrades extracellular matrix and contributes to delayed wound closure in apolipoprotein E knockout miceDecorin: A Growth Factor Antagonist for Tumor Growth InhibitionThe Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular DiseaseExtracellular Matrix, a Hard Player in AngiogenesisPivotal role for decorin in angiogenesisImproved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B.Early extracellular matrix changes are associated with later development of bronchiolitis obliterans syndrome after lung transplantation.Granzyme B releases vascular endothelial growth factor from extracellular matrix and induces vascular permeability.Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiologySoluble biglycan as a biomarker of inflammatory renal diseases.Granzyme-mediated regulation of host defense in the liver in experimental Leishmania donovani infection.Solar ultraviolet irradiation induces decorin degradation in human skin likely via neutrophil elastaseGranzyme B mediates both direct and indirect cleavage of extracellular matrix in skin after chronic low-dose ultraviolet light irradiation.Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation.Biglycan: a multivalent proteoglycan providing structure and signalsEpitelial-to-mesenchimal transition and invasion are upmodulated by tumor-expressed granzyme B and inhibited by docosahexaenoic acid in human colorectal cancer cells.The biology of the extracellular matrix: novel insights.Enhanced biglycan gene expression in the adipose tissues of obese women and its association with obesity-related genes and metabolic parameters.The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assembly.Topographical changes in extracellular matrix: Activation of TLR4 signaling and solid tumor progression.Beyond tissue injury-damage-associated molecular patterns, toll-like receptors, and inflammasomes also drive regeneration and fibrosis.Proteolytic control of TGF-β co-receptor activity by BMP-1/tolloid-like proteases revealed by quantitative iTRAQ proteomics.Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs.TAp73 loss favors Smad-independent TGF-β signaling that drives EMT in pancreatic ductal adenocarcinoma.Solution-Phase Crosstalk and Regulatory Interactions Between Multipotent Adult Progenitor Cells and Peripheral Blood Mononuclear CellsExtracellular matrix alterations in the Peyronie's disease.HIV replication in conjunction with granzyme B production by CCR5+ memory CD4 T cells: Implications for bystander cell and tissue pathologies.Bioengineering organized, multilamellar human corneal stromal tissue by growth factor supplementation on highly aligned synthetic substrates.Recombinant Decorin Fusion Protein Attenuates Murine Abdominal Aortic Aneurysm Formation and Rupture.Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension.Topical small molecule granzyme B inhibitor improves remodeling in a murine model of impaired burn wound healing.Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction.Serum decorin is a potential prognostic biomarker in patients with acute exacerbation of idiopathic pulmonary fibrosis
P2860
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P2860
Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-β1
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
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name
Granzyme B cleaves decorin, bi ...... transforming growth factor-β1
@ast
Granzyme B cleaves decorin, bi ...... transforming growth factor-β1
@en
Granzyme B cleaves decorin, bi ...... transforming growth factor-β1
@nl
type
label
Granzyme B cleaves decorin, bi ...... transforming growth factor-β1
@ast
Granzyme B cleaves decorin, bi ...... transforming growth factor-β1
@en
Granzyme B cleaves decorin, bi ...... transforming growth factor-β1
@nl
prefLabel
Granzyme B cleaves decorin, bi ...... transforming growth factor-β1
@ast
Granzyme B cleaves decorin, bi ...... transforming growth factor-β1
@en
Granzyme B cleaves decorin, bi ...... transforming growth factor-β1
@nl
P2093
P2860
P3181
P1433
P1476
Granzyme B cleaves decorin, bi ...... transforming growth factor-β1
@en
P2093
Amanda Vanden Hoek
Darryl A Knight
David J Granville
Hongyan Zhao
Marlo Shackleford
Tillie L Hackett
Wendy A Boivin
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0033163
P407
P577
2012-01-01T00:00:00Z