Kinetic cell-based morphological screening: prediction of mechanism of compound action and off-target effects - Wikidata - wikimedia - TriplyDB

Kinetic cell-based morphological screening: prediction of mechanism of compound action and off-target effects

Kinetic cell-based morphological screening: prediction of mechanism of compound action and off-target effects

http://www.wikidata.org/entity/Q28748600

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Target identification by image analysis The intestinal barrier as an emerging target in the toxicological assessment of mycotoxins Phenotypic pattern-based assay for dynamically monitoring host cellular responses to Salmonella infections Impedance responses reveal β₂-adrenergic receptor signaling pluridimensionality and allow classification of ligands with distinct signaling profiles Resveratrol as a pan-HDAC inhibitor alters the acetylation status of histone [corrected] proteins in human-derived hepatoblastoma cells Quantitative analysis of the anti-proliferative activity of combinations of selected iron-chelating agents and clinically used anti-neoplastic drugs The novel tubulin polymerization inhibitor MHPT exhibits selective anti-tumor activity against rhabdomyosarcoma in vitro and in vivo Evaluation of impedance-based label-free technology as a tool for pharmacology and toxicology investigations Chronic arsenic exposure in nanomolar concentrations compromises wound response and intercellular signaling in airway epithelial cells Wavelet-based multiscale analysis of bioimpedance data measured by electric cell-substrate impedance sensing for classification of cancerous and normal cells.In vitro Assessment of Hg Toxicity in Hepatocytes from Heat-Stressed Atlantic Salmon.Alignment of time-resolved data from high throughput experiments.Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage.Dexmedetomidine attenuates hypoxia/reoxygenation injury in primary neonatal rat cardiomyocytes 0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop Advances in miniaturized instruments for genomics.Identification of eusynstyelamide B as a potent cell cycle inhibitor following the generation and screening of an ascidian-derived extract library using a real time cell analyzer.Comparative analysis of dynamic cell viability, migration and invasion assessments by novel real-time technology and classic endpoint assays.Coibamide A, a natural lariat depsipeptide, inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts.Target identification for small bioactive molecules: finding the needle in the haystack.An RNA aptamer provides a novel approach for the induction of apoptosis by targeting the HPV16 E7 oncoprotein.Arsenic alters ATP-dependent Ca²+ signaling in human airway epithelial cell wound response.Real-time monitoring of flavivirus induced cytopathogenesis using cell electric impedance technology.The protease-activated receptor-2-specific agonists 2-aminothiazol-4-yl-LIGRL-NH2 and 6-aminonicotinyl-LIGRL-NH2 stimulate multiple signaling pathways to induce physiological responses in vitro and in vivo Antioxidant and anti-inflammatory activity of Ocimum labiatum extract and isolated labdane diterpenoid.Modifying effects of vitamin E on chlorpyrifos toxicity in atlantic salmon Cell growth density modulates cancer cell vascular invasion via Hippo pathway activity and CXCR2 signaling.Acute Toxicity-Supported Chronic Toxicity Prediction: A k-Nearest Neighbor Coupled Read-Across Strategy.Ormeloxifene suppresses desmoplasia and enhances sensitivity of gemcitabine in pancreatic cancer Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins.An approach to "escape from flatland": chemo-enzymatic synthesis and biological profiling of a library of bridged bicyclic compounds.Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced.The Inhibition of Mast Cell Activation of Radix Paeoniae alba Extraction Identified by TCRP Based and Conventional Cell Function Assay Systems Ruthenium(II) Complexes with 2-Phenylimidazo[4,5-f][1,10]phenanthroline Derivatives that Strongly Combat Cisplatin-Resistant Tumor Cells From fighting depression to conquering tumors: a novel tricyclic thiazepine compound as a tubulin polymerization inhibitor Airway epithelial cell exposure to distinct e-cigarette liquid flavorings reveals toxicity thresholds and activation of CFTR by the chocolate flavoring 2,5-dimethypyrazine Label-free drug discovery.Using label-free screening technology to improve efficiency in drug discovery.Real-time cellular analysis for quantitative detection of functional Clostridium difficile toxin in stool.Tetradecylthioacetic acid inhibits proliferation of human SW620 colon cancer cells--gene expression profiling implies endoplasmic reticulum stress.

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P2860

Kinetic cell-based morphological screening: prediction of mechanism of compound action and off-target effects

http://www.wikidata.org/entity/Q28748600

description

2009 nî lūn-bûn

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2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2009 թվականի հուլիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Kinetic cell-based morphologic ...... action and off-target effects

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Kinetic cell-based morphologic ...... action and off-target effects

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Kinetic cell-based morphologic ...... action and off-target effects

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type

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Kinetic cell-based morphologic ...... action and off-target effects

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Kinetic cell-based morphologic ...... action and off-target effects

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Kinetic cell-based morphologic ...... action and off-target effects

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Kinetic cell-based morphologic ...... action and off-target effects

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Kinetic cell-based morphologic ...... action and off-target effects

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Kinetic cell-based morphologic ...... action and off-target effects

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J.CHEMBIOL.2009.05.011

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Chemistry and Biology

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Kinetic cell-based morphologic ...... action and off-target effects

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Biao Xi

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Michelle R Gaylord

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Peifang Ye

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Xiaobo Wang

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Yama A Abassi

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Discovering potent and selective reversible inhibitors of enzymes in complex proteomes.

New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products.

Tamoxifen-induced enhancement of calcium signaling in glioma and MCF-7 breast cancer cells.

In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities.

Integrating high-content screening and ligand-target prediction to identify mechanism of action.

Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro

Failing the public health--rofecoxib, Merck, and the FDA.

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712-23

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1505957

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7

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