Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
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We are ageingRapalogs in cancer prevention: anti-aging or anticancer?Advances in targeting signal transduction pathwaysEvolution of sexually dimorphic longevity in humansBig mice die young but large animals live longerHormesis, cell death and aging.TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists.Selective anti-cancer agents as anti-aging drugsWhy the disposable soma theory cannot explain why women live longer and why we age.Metformin and sex: Why suppression of aging may be harmful to young male mice.Gerosuppression in confluent cells.The contribution of diseases to the male-female disability-survival paradox in the very old: results from the Newcastle 85+ study.Hormesis does not make sense except in the light of TOR-driven aging.Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health.Molecular damage in cancer: an argument for mTOR-driven agingExceptional longevity is associated with decreased reproduction.Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging.Geroconversion: irreversible step to cellular senescenceNew strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators.Rejuvenating immunity: "anti-aging drug today" eight years later.Transitions among Health States Using 12 Measures of Successful Aging in Men and Women: Results from the Cardiovascular Health StudyEctopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberineAnswering the ultimate question "what is the proximal cause of aging?"Recent discoveries in the cycling, growing and aging of the p53 fieldMechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging.Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response.Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI's provocative questions.One-carbon metabolism: an aging-cancer crossroad for the gerosuppressant metforminM(o)TOR of aging: MTOR as a universal molecular hypothalamusRapamycin extends life- and health span because it slows aging.Early and extraordinary peaks in physical performance come with a longevity cost.Aging is not programmed: genetic pseudo-program is a shadow of developmental growth.Overactive mTOR signaling leads to endometrial hyperplasia in aged women and mice.Sex differences in telomeres and lifespan.M(o)TOR of pseudo-hypoxic state in aging: rapamycin to the rescue.DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility.Prevention of age-associated neurodegeneration and promotion of healthy brain ageing in female Wistar rats by long term use of bacosides.Sex-specific regulation of aging in Caenorhabditis elegans.Effects of N-acetyl-L-cysteine on lifespan, locomotor activity and stress-resistance of 3 species with different lifespans
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P2860
Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
@ast
Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
@en
Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
@nl
type
label
Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
@ast
Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
@en
Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
@nl
prefLabel
Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
@ast
Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
@en
Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
@nl
P2860
P3181
P356
P1433
P1476
Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
@en
P2860
P304
P3181
P356
10.18632/AGING.100149
P407
P577
2010-05-01T00:00:00Z