Directional and balancing selection in human beta-defensins
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Population genetic tools for dissecting innate immunity in humansUnderstanding rare and common diseases in the context of human evolutionEvidence of convergent evolution in humans and macaques supports an adaptive role for copy number variation of the β-defensin-2 geneDetecting Genomic Signatures of Natural Selection with Principal Component Analysis: Application to the 1000 Genomes DataHomozygosity and risk of childhood death due to invasive bacterial disease.Molecular diversity of antimicrobial effectors in the oyster Crassostrea gigas.Copy number variation in the human genome and its implication in autoimmunity.A common mutation in the defensin DEFB126 causes impaired sperm function and subfertility.Comparative genomics and evolution of the alpha-defensin multigene family in primatesRefinement of primate copy number variation hotspots identifies candidate genomic regions evolving under positive selection.Haplotype variation in the ACE gene in global populations, with special reference to India, and an alternative model of evolution of haplotypes.Trans-Species Polymorphism in Immune Genes: General Pattern or MHC-Restricted Phenomenon?A signature of balancing selection in the region upstream to the human UGT2B4 gene and implications for breast cancer risk.Candidate targets of balancing selection in the genome of Staphylococcus aureusPerspectives on the evolutionary ecology of arthropod antimicrobial peptides.Immune genes and divergent antimicrobial peptides in flies of the subgenus Drosophila.Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity GenesConvergent Balancing Selection on an Antimicrobial Peptide in Drosophila.Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variationThe potential for adaptive maintenance of diversity in insect antimicrobial peptidesCRS-peptides: unique defense peptides of mouse Paneth cells.Bovine β-defensin gene family: opportunities to improve animal health?IL-22 Up-Regulates β-Defensin-2 Expression in Human Alveolar Epithelium via STAT3 but Not NF-κB Signaling Pathway.Prediction of the impact of coding missense and nonsense single nucleotide polymorphisms on HD5 and HBD1 antibacterial activity against Escherichia coli.A worldwide analysis of beta-defensin copy number variation suggests recent selection of a high-expressing DEFB103 gene copy in East Asia.Balancing selection at a frog antimicrobial peptide locus: fluctuating immune effector alleles?Molecular diversity of the antimicrobial domain of beta-defensin 3 and homologous peptidesThe Evolution of Innate Immune Genes: Purifying and Balancing Selection on β-Defensins in Waterfowl.Lineage-specific evolution of T-cell immunoglobulin and mucin domain 1 gene in the primates.Evolutionary analysis of the contact system indicates that kininogen evolved adaptively in mammals and in human populations.Signatures of selection in the Iberian honey bee (Apis mellifera iberiensis) revealed by a genome scan analysis of single nucleotide polymorphisms.Using human demographic history to infer natural selection reveals contrasting patterns on different families of immune genes.
P2860
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P2860
Directional and balancing selection in human beta-defensins
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Directional and balancing selection in human beta-defensins
@ast
Directional and balancing selection in human beta-defensins
@en
Directional and balancing selection in human beta-defensins
@nl
type
label
Directional and balancing selection in human beta-defensins
@ast
Directional and balancing selection in human beta-defensins
@en
Directional and balancing selection in human beta-defensins
@nl
prefLabel
Directional and balancing selection in human beta-defensins
@ast
Directional and balancing selection in human beta-defensins
@en
Directional and balancing selection in human beta-defensins
@nl
P2860
P3181
P356
P1476
Directional and balancing selection in human beta-defensins
@en
P2093
Edward J Hollox
John A L Armour
P2860
P2888
P3181
P356
10.1186/1471-2148-8-113
P407
P577
2008-04-16T00:00:00Z
P5875
P6179
1004879581