Disruption of the A-kinase anchoring domain in flagellar radial spoke protein 3 results in unregulated axonemal cAMP-dependent protein kinase activity and abnormal flagellar motility
about
The Chlamydomonas genome reveals the evolution of key animal and plant functions.Radial spoke protein 3 is a mammalian protein kinase A-anchoring protein that binds ERK1/2Loss of ASP but not ROPN1 reduces mammalian ciliary motilityIC138 defines a subdomain at the base of the I1 dynein that regulates microtubule sliding and flagellar motilityChlamydomonas mutants display reversible deficiencies in flagellar beating and axonemal assembly.A role for p38 MAPK in the regulation of ciliary motion in a eukaryote.Application of phosphoproteomics to find targets of casein kinase 1 in the flagellum of chlamydomonas.FAP206 is a microtubule-docking adapter for ciliary radial spoke 2 and dynein cRegulation of ciliary motility: conserved protein kinases and phosphatases are targeted and anchored in the ciliary axonemeAn axonemal PP2A B-subunit is required for PP2A localization and flagellar motility.Retained duplicate genes in green alga Chlamydomonas reinhardtii tend to be stress responsive and experience frequent response gains.The versatile molecular complex component LC8 promotes several distinct steps of flagellar assembly.A conserved CaM- and radial spoke associated complex mediates regulation of flagellar dynein activityCryoelectron tomography reveals doublet-specific structures and unique interactions in the I1 dynein.A flagellar A-kinase anchoring protein with two amphipathic helices forms a structural scaffold in the radial spoke complex.Regulation of dynein-driven microtubule sliding by the axonemal protein kinase CK1 in Chlamydomonas flagellaAlcohol-induced ciliary dysfunction targets the outer dynein arm.Nitric oxide-dependent cilia regulatory enzyme localization in bovine bronchial epithelial cells.The mouse radial spoke protein 3 is a nucleocytoplasmic shuttling protein that promotes neurogenesis.Subcellular localization and function of mouse radial spoke protein 3 in mammalian cells and central nervous system.A microtubule-dynein tethering complex regulates the axonemal inner dynein f (I1).PKA, PP1, and DC1 phosphorylation mediate alcohol-induced ciliary dysfunction in Chlamydomonas reinhardtii
P2860
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P2860
Disruption of the A-kinase anchoring domain in flagellar radial spoke protein 3 results in unregulated axonemal cAMP-dependent protein kinase activity and abnormal flagellar motility
description
2006 nî lūn-bûn
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2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2006 թվականի հունիսին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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name
Disruption of the A-kinase anc ...... nd abnormal flagellar motility
@ast
Disruption of the A-kinase anc ...... nd abnormal flagellar motility
@en
type
label
Disruption of the A-kinase anc ...... nd abnormal flagellar motility
@ast
Disruption of the A-kinase anc ...... nd abnormal flagellar motility
@en
prefLabel
Disruption of the A-kinase anc ...... nd abnormal flagellar motility
@ast
Disruption of the A-kinase anc ...... nd abnormal flagellar motility
@en
P2093
P2860
P356
P1476
Disruption of the A-kinase anc ...... nd abnormal flagellar motility
@en
P2093
Anne R Gaillard
Branch Craige
Jeanne M Rhea
Laura A Fox
Winfield S Sale
P2860
P304
P356
10.1091/MBC.E06-02-0095
P407
P577
2006-06-01T00:00:00Z