Extensive phosphorylation of Smoothened in Hedgehog pathway activation - Wikidata - wikimedia - TriplyDB

Extensive phosphorylation of Smoothened in Hedgehog pathway activation

Extensive phosphorylation of Smoothened in Hedgehog pathway activation

http://www.wikidata.org/entity/Q28770067

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The hedgehog receptor patched is involved in cholesterol transport Decoding the phosphorylation code in Hedgehog signal transduction Biography of Philip A. Beachy Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function Robust enrichment of phosphorylated species in complex mixtures by sequential protein and peptide metal-affinity chromatography and analysis by tandem mass spectrometry.Smoothened goes molecular: new pieces in the hedgehog signaling puzzle Capping Enzyme mRNA-cap/RNGTT Regulates Hedgehog Pathway Activity by Antagonizing Protein Kinase A Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal.Mechanism and evolution of cytosolic Hedgehog signal transduction USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila.Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus.Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila.Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling.The role of kinases in the Hedgehog signalling pathway.Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator Activation of heterotrimeric G proteins by Smoothened.The contributions of protein kinase A and smoothened phosphorylation to hedgehog signal transduction in Drosophila melanogaster.Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses Clinical implications of hedgehog signaling pathway inhibitors Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2 Regulation of smoothened by Drosophila G-protein-coupled receptor kinases.A broadly conserved g-protein-coupled receptor kinase phosphorylation mechanism controls Drosophila smoothened activity.Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila.RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail.Regulation of Hedgehog signaling by ubiquitination.Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.Molecular Characterization of Bovine SMO Gene and Effects of Its Genetic Variations on Body Size Traits in Qinchuan Cattle (Bos taurus).Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation.Sequential phosphorylation of smoothened transduces graded hedgehog signaling.

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P2860

Extensive phosphorylation of Smoothened in Hedgehog pathway activation

http://www.wikidata.org/entity/Q28770067

description

2004 nî lūn-bûn

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2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

@zh-hk

2004年論文

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2004年論文

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2004年论文

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name

Extensive phosphorylation of Smoothened in Hedgehog pathway activation

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Extensive phosphorylation of Smoothened in Hedgehog pathway activation

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type

label

Extensive phosphorylation of Smoothened in Hedgehog pathway activation

@ast

Extensive phosphorylation of Smoothened in Hedgehog pathway activation

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prefLabel

Extensive phosphorylation of Smoothened in Hedgehog pathway activation

@ast

Extensive phosphorylation of Smoothened in Hedgehog pathway activation

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PNAS.0408093101

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Extensive phosphorylation of Smoothened in Hedgehog pathway activation

@en

P2093

Chi Zhang

http://www.w3.org/2001/XMLSchema#string

Lawrence Lum

http://www.w3.org/2001/XMLSchema#string

Philip A Beachy

http://www.w3.org/2001/XMLSchema#string

Yurong Guo

http://www.w3.org/2001/XMLSchema#string

P2860

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system

Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity

Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2

Hedgehog signaling in animal development: paradigms and principles

Patched acts catalytically to suppress the activity of Smoothened

The Hedgehog response network: sensors, switches, and routers

Tissue repair and stem cell renewal in carcinogenesis

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17900-7

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908689

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10.1073/PNAS.0408093101

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52

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101

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Elizabeth H Williams

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2004-12-28T00:00:00Z

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8130696

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15598741

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phosphorylation

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535705

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