Translation of 5' leaders is pervasive in genes resistant to eIF2 repression
about
MiRImpact, a new bioinformatic method using complete microRNA expression profiles to assess their overall influence on the activity of intracellular molecular pathways.What Is the Impact of mRNA 5' TL Heterogeneity on Translational Start Site Selection and the Mammalian Cellular Phenotype?Flavivirus Infection Uncouples Translation Suppression from Cellular Stress ResponsesFour translation initiation pathways employed by the leaderless mRNA in eukaryotesA Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian TranslationRiboGalaxy: A browser based platform for the alignment, analysis and visualization of ribosome profiling data.New frontiers in translational control of the cancer genomeRibosome profiling reveals the what, when, where and how of protein synthesisThe small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assemblyInsights into the mechanisms of eukaryotic translation gained with ribosome profilingOxygen and glucose deprivation induces widespread alterations in mRNA translation within 20 minutesThe Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal ProteinsThe effect of heterogeneous Transcription Start Sites (TSS) on the translatome: implications for the mammalian cellular phenotype.UPR(mt)-mediated cytoprotection and organismal aging.Translation complex profile sequencing to study the in vivo dynamics of mRNA-ribosome interactions during translation initiation, elongation and termination.Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response.Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.Simple and inexpensive ribosome profiling analysis of mRNA translation.Death of a dogma: eukaryotic mRNAs can code for more than one protein.Upstream ORFs are prevalent translational repressors in vertebrates.Estimation of ribosome profiling performance and reproducibility at various levels of resolution.Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish.Systematic analysis of the PTEN 5' leader identifies a major AUU initiated proteoform.Real-Time Imaging of Translation on Single mRNA Transcripts in Live CellsNowhere to hide: unconventional translation yields cryptic peptides for immune surveillancePKR Activation Favors Infectious Pancreatic Necrosis Virus Replication in Infected Cells.Improved Identification and Analysis of Small Open Reading Frame Encoded Polypeptides.Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress.Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation.The ribosome-engaged landscape of alternative splicing.Ribonuclease selection for ribosome profiling.Sliding of a 43S ribosomal complex from the recognized AUG codon triggered by a delay in eIF2-bound GTP hydrolysisTime-Resolved Proteomics Extends Ribosome Profiling-Based Measurements of Protein Synthesis Dynamics.Response of Three Different Viruses to Interferon Priming and Dithiothreitol Treatment of Avian Cells.The impact of the phosphomimetic eIF2αS/D on global translation, reinitiation and the integrated stress response is attenuated in N2a cells.Upstream Open Reading Frames Differentially Regulate Gene-specific Translation in the Integrated Stress ResponseDecoding sORF translation - from small proteins to gene regulation.A researcher's guide to the galaxy of IRESs.Comparative survey of the relative impact of mRNA features on local ribosome profiling read density.Small proteins encoded by unannotated ORFs are rising stars of the proteome, confirming shortcomings in genome annotations and current vision of an mRNA.
P2860
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P2860
Translation of 5' leaders is pervasive in genes resistant to eIF2 repression
description
2015 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2015
@ast
scientific journal article
@en
wetenschappelijk artikel (gepubliceerd op 2015/01/26)
@nl
wissenschaftlicher Artikel
@de
наукова стаття, опублікована в січні 2015
@uk
مقالة علمية (نشرت في 26-1-2015)
@ar
name
Translation of 5' leaders is pervasive in genes resistant to eIF2 repression
@ast
Translation of 5' leaders is pervasive in genes resistant to eIF2 repression
@en
type
label
Translation of 5' leaders is pervasive in genes resistant to eIF2 repression
@ast
Translation of 5' leaders is pervasive in genes resistant to eIF2 repression
@en
prefLabel
Translation of 5' leaders is pervasive in genes resistant to eIF2 repression
@ast
Translation of 5' leaders is pervasive in genes resistant to eIF2 repression
@en
P2093
P2860
P50
P3181
P356
P1433
P1476
Translation of 5' leaders is pervasive in genes resistant to eIF2 repression
@en
P2093
Ciara Fahey
Elaine M Kenny
Patrick B F O'Connor
Paul Cormican
P2860
P304
P3181
P356
10.7554/ELIFE.03971
P407
P577
2015-01-26T00:00:00Z