Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy

Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy

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http://www.wikidata.org/entity/Q28830592
Synthesis and investigation of novel benzimidazole derivatives as antifungal agentsA flow cytometry-based screen identifies MBNL1 modulators that rescue splicing defects in myotonic dystrophy type I.In silico discovery of substituted pyrido[2,3-d]pyrimidines and pentamidine-like compounds with biological activity in myotonic dystrophy models.The Emerging Role of RNA as a Therapeutic Target for Small Molecules.Development of pharmacophore models for small molecules targeting RNA: Application to the RNA repeat expansion in myotonic dystrophy type 1.Biochemical and cell biological assays to identify and characterize DNA helicase inhibitors.Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands.Design of a "Mini" Nucleic Acid Probe for Cooperative Binding of an RNA-Repeated Transcript Associated with Myotonic Dystrophy Type 1.CRISPR/Cas9-Induced (CTG⋅CAG)n Repeat Instability in the Myotonic Dystrophy Type 1 Locus: Implications for Therapeutic Genome Editing.Sensing the impact of environment on small molecule differentiation of RNA sequences.Use of a redox probe for an electrochemical RNA-ligand binding assay in microliter droplets.Insights into the development of chemical probes for RNA
P2860

Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy

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http://www.wikidata.org/entity/Q28830592
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2015 nî lūn-bûn
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2015 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2015 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年學術文章
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name
Studying a Drug-like, RNA-Focu ...... Toxicity in Myotonic Dystrophy
@ast
Studying a Drug-like, RNA-Focu ...... Toxicity in Myotonic Dystrophy
@en
type
label
Studying a Drug-like, RNA-Focu ...... Toxicity in Myotonic Dystrophy
@ast
Studying a Drug-like, RNA-Focu ...... Toxicity in Myotonic Dystrophy
@en
prefLabel
Studying a Drug-like, RNA-Focu ...... Toxicity in Myotonic Dystrophy
@ast
Studying a Drug-like, RNA-Focu ...... Toxicity in Myotonic Dystrophy
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932
P356
P1433
P1476
Studying a Drug-like, RNA-Focu ...... Toxicity in Myotonic Dystrophy
@en
P2093
P2860
P304
P31
P356
10.1021/ACSCHEMBIO.5B00430
P407
P433
P478
P577
P698
P932