In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice
about
Bacterial ProteasomesThe application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosisThe pup-proteasome system of Mycobacterium tuberculosisThe Pup-Proteasome System of MycobacteriaMycobacterium tuberculosis: success through dormancyProkaryotic ubiquitin-like protein modificationInhibitors selective for mycobacterial versus human proteasomesStructural Insights on the Mycobacterium tuberculosis Proteasomal ATPase MpaStructural basis for the assembly and gate closure mechanisms of the Mycobacterium tuberculosis 20S proteasomeFellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasomeBinding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradationStructures of Pup ligase PafA and depupylase Dop from the prokaryotic ubiquitin-like modification pathwayGlycolytic and Non-glycolytic Functions of Mycobacterium tuberculosis Fructose-1,6-bisphosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating BacilliBacterial Proteasomes: Mechanistic and Functional InsightsMycobacterial genes essential for the pathogen's survival in the hostProteasomal protein degradation in Mycobacteria is dependent upon a prokaryotic ubiquitin-like proteinSimultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivoEvaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression4'-Phosphopantetheinyl transferase PptT, a new drug target required for Mycobacterium tuberculosis growth and persistence in vivoMolecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosisA novel copper-responsive regulon in Mycobacterium tuberculosis"Depupylation" of prokaryotic ubiquitin-like protein from mycobacterial proteasome substratesMycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochloriteThe mycobacterial Mpa-proteasome unfolds and degrades pupylated substrates by engaging Pup's N-terminusFunctional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acidsBacterial proteasome activator bpa (rv3780) is a novel ring-shaped interactor of the mycobacterial proteasomeProteasomal control of cytokinin synthesis protects Mycobacterium tuberculosis against nitric oxideProkaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected]Deletion of dop in Mycobacterium smegmatis abolishes pupylation of protein substrates in vivoAn IPTG Inducible Conditional Expression System for MycobacteriaThe spectrum of latent tuberculosis: rethinking the biology and intervention strategiesRecombinant Mycobacterium bovis BCG as an HIV vaccine vector.Distinct specificities of Mycobacterium tuberculosis and mammalian proteasomes for N-acetyl tripeptide substrates.Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome.Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.Contrasting persistence strategies in Salmonella and MycobacteriumThe Mycobacterium tuberculosis proteasome active site threonine is essential for persistence yet dispensable for replication and resistance to nitric oxide.To catch a killer. What can mycobacterial models teach us about Mycobacterium tuberculosis pathogenesis?Helicobacter pylori gene silencing in vivo demonstrates urease is essential for chronic infection.VapC toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins.
P2860
Q26778726-4C13D05C-2AE6-467C-9B03-9801EE1DA2EEQ26795478-A8006ABD-70B2-400B-AE5E-C8FD0B5CC2BDQ26823027-DEF6B515-0C70-447B-ABA9-D40446F04457Q26825089-96EEBAF5-55B1-44D8-BCDA-73C8C4BA883CQ26852023-9E6C20C2-F422-4778-B191-311348912AC7Q26998484-BBE72A2B-BA99-46DA-BB05-35740E2A329CQ27657451-3C3CC41F-4C1D-450D-AD18-2E0283B28332Q27657813-2D4A27C6-C297-4865-A638-08477AC421F1Q27661499-812711CA-7BC9-47BE-9C83-90559EC48851Q27662412-A54236AC-0BA9-48D5-81BF-0D14F897565BQ27665108-8BFF0049-A81A-4579-AD0A-70A0156F195FQ27671633-1A09E3DD-0CE2-444D-88E2-7036932CB1FBQ27674487-FAB1D32A-C9E4-455A-BFAB-89C3B914E66DQ28073414-D7641BBF-4C9D-440A-8767-09502143B2E5Q28083739-7E9C3490-1BEA-4B7E-A625-4162CEC98149Q28301654-A2C5ADDA-6F66-416B-A4A6-E29A573F5F7EQ28476622-F20101AE-346E-4D60-8EA1-81BA4F332A29Q28477282-B6E705AC-EA0E-465F-9157-42267F70C73CQ28484764-7089D22D-615C-4A32-9227-98D37E7A0DD5Q28486486-913F702F-97BA-4CED-B525-416262EBDEDBQ28486641-A4E652F0-AD1B-414E-A44A-E1542AC4148EQ28486654-7F15F4C7-0925-451B-B4AC-2C57616E4FD0Q28486777-1603D27A-FF6A-4EC3-9A81-AD01C7006D61Q28486892-1EC8BA3D-6815-46FA-929C-13EE38193904Q28487127-89CD552D-13ED-4A75-9E31-B4ADB31B54B4Q28487276-7C41039F-B5BB-479A-A9A0-C7867C38976CQ28487570-01CBA46F-8613-4899-AB18-8D8F0174542DQ28487609-8389909A-7C18-40E9-8192-8DDF6DBC1278Q28501857-DD03F5A0-31E1-452E-90A9-A3B4FCB67BCDQ28547068-D533DBC7-C346-4FEE-B668-3D96C3D0B130Q29619404-87EB57D6-EC79-40A6-880B-0EAC8EB8A549Q30387447-068AB080-BFAF-48CA-91F1-B11228CFFEDEQ33373239-41DFE1AA-7D18-4AF3-8DAC-6F394F747B83Q33607221-7C40DB37-D71E-45BA-AA51-9AE27A6396F8Q33620526-DCFC1FBE-8FBC-4589-9AA6-08657B6687A8Q33654036-99CE3032-0E9D-42CE-9287-B71BD9BC344AQ33658714-BAD74E0D-E0F8-4385-8363-6809D21B0154Q33876370-39F58E3B-571F-4403-AE13-A866EDEC3872Q33880860-48719948-9B7F-4304-BE85-EB11CBECECD7Q33955336-3E0F4794-0B69-445A-955B-B1EA53E36FA2
P2860
In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice
description
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im Dezember 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
wetenschappelijk artikel (gepubliceerd op 2007/12/01)
@nl
наукова стаття, опублікована в грудні 2007
@uk
مقالة علمية (نشرت في ديسمبر 2007)
@ar
name
In vivo gene silencing identif ...... he bacteria to persist in mice
@ast
In vivo gene silencing identif ...... he bacteria to persist in mice
@en
type
label
In vivo gene silencing identif ...... he bacteria to persist in mice
@ast
In vivo gene silencing identif ...... he bacteria to persist in mice
@en
prefLabel
In vivo gene silencing identif ...... he bacteria to persist in mice
@ast
In vivo gene silencing identif ...... he bacteria to persist in mice
@en
P2093
P2860
P356
P1433
P1476
In vivo gene silencing identif ...... he bacteria to persist in mice
@en
P2093
Dirk Schnappinger
Mercedes Monteleone
Sabine Ehrt
Sheetal Gandotra
Wolfgang Hillen
P2860
P2888
P304
P356
10.1038/NM1683
P407
P577
2007-12-01T00:00:00Z
P5875
P6179
1046391323