Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption
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Behavioral and antioxidant activity of a tosylbenz[g]indolamine derivative. A proposed better profile for a potential antipsychotic agentPredicting volume of distribution with decision tree-based regression methods using predicted tissue:plasma partition coefficientsIn silico screening for novel inhibitors of DNA polymerase III alpha subunit of Mycobacterium tuberculosis (MtbDnaE2, H37Rv)Potential Compounds for Oral Cancer Treatment: Resveratrol, Nimbolide, Lovastatin, Bortezomib, Vorinostat, Berberine, Pterostilbene, Deguelin, Andrographolide, and ColchicineComputation of the physio-chemical properties and data mining of large molecular collections.Library design concepts and implementation strategies.In silico predictions of drug solubility and permeability: two rate-limiting barriers to oral drug absorption.Valproic acid-hydrophilic cyclodextrin complexes and valproic acid-solid dispersions: evaluation of their potential pharmaceutical use.Inhibition of recombinant cytochrome P450 isoforms 2D6 and 2C9 by diverse drug-like moleculesHigh-throughput evaluation of relative cell permeability between peptoids and peptides.The Simbios National Center: Systems Biology in Motion.Understanding peroral absorption: regulatory aspects and contemporary approaches to tackling solubility and permeability hurdlesMedicinal chemical properties of successful central nervous system drugsThe design of orally bioavailable 2, 5-diketopiperazine oxytocin antagonists: from concept to clinical candidate for premature labor.BDDCS applied to over 900 drugs.Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ringe-molecular shapes and properties.The twin drug approach for novel nicotinic acetylcholine receptor ligands.Comparison of the applicability of mass spectrometer ion sources using a polarity- molecular weight scattergram with a 600 sample in-house chemical library.Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV.Biomolecular chemistry of isopropyl fibratesPrediction methods and databases within chemoinformatics: emphasis on drugs and drug candidates.Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for inhibiting amyloid beta formation: in silico and in vitro study.Computational models to predict aqueous drug solubility, permeability and intestinal absorption.truPK -- human pharmacokinetic models for quantitative ADME prediction.Evaluation and suggested improvements of the Biopharmaceutics Classification System (BCS).Prediction of human pharmacokinetics--gastrointestinal absorption.Modeling kinetics of subcellular disposition of chemicals.Mechanisms of activity-dependent plasticity in cellular nitric oxide-cGMP signalingPharmacokinetics of the Antischistosomal Lead Ozonide OZ418 in Uninfected Mice Determined by Liquid Chromatography-Tandem Mass SpectrometryWhat has polar surface area ever done for drug discovery?Going further than Lipinski's rule in drug design.Pros and cons of methods used for the prediction of oral drug absorption.Synthesis, characterization and in vitro anticancer activity of C-5 curcumin analogues with potential to inhibit TNF-α-induced NF-κB activation.Discovery of MK-3207: A Highly Potent, Orally Bioavailable CGRP Receptor AntagonistDesigning, synthesis, and antimicrobial action of oxazoline and thiazoline derivatives of fatty acid esters.Drug delivery characteristics of the progenitor bronchial epithelial cell line VA10.Pharmacophore, QSAR, and ADME based semisynthesis and in vitro evaluation of ursolic acid analogs for anticancer activity.Probing the presence of the ligand-binding haem in cellular nitric oxide receptors.Optimization of Pharmacokinetics through Manipulation of Physicochemical Properties in a Series of HCV Inhibitors.
P2860
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P2860
Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption
description
1999 nî lūn-bûn
@nan
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Rapid calculation of polar mol ...... ction of intestinal absorption
@ast
Rapid calculation of polar mol ...... ction of intestinal absorption
@en
type
label
Rapid calculation of polar mol ...... ction of intestinal absorption
@ast
Rapid calculation of polar mol ...... ction of intestinal absorption
@en
prefLabel
Rapid calculation of polar mol ...... ction of intestinal absorption
@ast
Rapid calculation of polar mol ...... ction of intestinal absorption
@en
P3181
P356
P1476
Rapid calculation of polar mol ...... ction of intestinal absorption
@en
P2093
David E. Clark
P304
P3181
P356
10.1021/JS9804011
P407
P577
1999-08-01T00:00:00Z